- ►cell.com I Prokopenko, MI McCarthy, CM Lindgren - Trends in Genetics, 2008 - Elsevier Over the past two years, there has been a spectacular change in the capacity to identify common
genetic variants that contribute to predisposition to complex multifactorial phenotypes such as
type 2 diabetes (T2D). The principal advance has been the ability to undertake surveys of ... Cited by 15 - Related articles - All 7 versions
H Staiger, F Machicao, K Kantartzis, SA Schäfer, K … - PLoS ONE, 2008 - pubmedcentral.nih.gov Genome-wide association (GWA) studies identified a series of novel type 2 diabetes risk
loci. Most of them were subsequently demonstrated to affect insulin secretion of pancreatic
β-cells. Very recently, a meta-analysis of GWA data revealed nine additional risk loci with ... Cited by 10 - Related articles - All 6 versions
- ►oxfordjournals.org KL Mohlke, M Boehnke, GR Abecasis - Human Molecular Genetics, 2008 - Oxford Univ Press Genome-wide association studies are providing new insights into the genetic basis of metabolic
and cardiovascular traits. In the past 3 years, common variants in 50 loci have been strongly
associated with metabolic and cardiovascular traits. Several of these loci have implicated ... Cited by 8 - Related articles - All 6 versions
DK Sanghera, L Been, L Ortega, GS Wander, NK … - Journal of Human …, 2009 - nature.com A recent meta-analysis on three genome-wide association (GWA) scans identified six loci
(NOTCH2, THADA, ADAMTS9, JAZF1, CDC123/CAMKID and TSPAN8/LGRS) highly associated
with type II diabetes (T2D) in Caucasians. This investigation seeks to confirm this ... Cited by 3 - Related articles - All 3 versions
T Sparsø, N Grarup, C Andreasen, A Albrechtsen, J … - Diabetologia, 2009 - Springer Abstract Aims/hypothesis The list of validated type 2 diabetes susceptibility variants has recently
been expanded from three to 19. The variants identified are common and have low penetrance
in the general population. The aim of the study is to investigate the combined effect of the ... Cited by 2 - Related articles - All 2 versions
A Haupt, M Guthoff, SA Schafer, K Kirchhoff, F … - Journal of Clinical …, 2009 - Endocrine Soc Results: We observed a 28% decline in insulin secretion with increment of risk alleles (P
0.0018). Subjects with two to four risk alleles displayed a progressive decline in ß-cell
function, which was not further enhanced in carriers of five to seven alleles. After ... Cited by 4 - Related articles - All 3 versions
- ►spendocrinologia.org.pe [PDF] H Staiger, F Machicao, A Fritsche, HU Haring - Endocrine Reviews, 2009 - Endocrine Soc Type 2 diabetes mellitus is a complex metabolic disease that is caused by insulin resistance
and β-cell dysfunction. Furthermore, type 2 diabetes has an evident genetic component and
represents a polygenic disease. During the last decade, considerable progress was ... Related articles - All 4 versions
MGM Wolfs, MH Hofker, C Wijmenga, TW van Haeften - 2009 - pubmedcentral.nih.gov Type 2 diabetes is a disorder of dysregulated glucose homeostasis. Normal glucose homeostasis
is a complex process involving several interacting mechanisms, such as insulin secretion, insulin
sensitivity, glucose production, and glucose uptake. The dysregulation of one or more of ... Cited by 1 - Related articles - All 3 versions
MAS Dehwah, Z Shuang, WZ Hua, W Min, QY … - Journal of Applied …, 2009 - scialert.net J. Applied Sci, 9 (19); 3407-3423, 2009 2007). Family, history of T2DM has a significant, independent
and graded association with the prevalence of T2DM. In twins studies, very high concordance
(55 to 100%) for T2DM has been reported among monozygotic (MZ) twins (Newman et ... Related articles - All 6 versions
JM Willemsen, EM Eekhoff, EJ de Geus, M Leen - tweelingenregister.org Annemarie M. Simonis-Bik1, Giel Nijpels2, Timon W. van Haeften3, Jeanine J. Houwing-
Duistermaat4, Dorret I. Boomsma5, Erwin Reiling6, Els C van Hove6, Michaela Diamant1, Mark
HH Kramer1, Robert J. Heine1,2,7, J. Antonie Maassen1,6, P. Eline Slagboom4, ... Related articles - View as HTML
