P Concannon, SS Rich, GT Nepom - New England Journal of Medicine, 2009 - content.nejm.org In 1976, the noted human geneticist James Neel titled a book chapter "Diabetes
Mellitus: A Geneticist's Nightmare." 1 Over the past 30 years, however, the
phenotypic and genetic heterogeneity of diabetes has been painstakingly ... Cited by 8 - Related articles - All 2 versions
SE Baranzini - Current Opinion in Immunology, 2009 - Elsevier Modern tools for genetic analysis are producing a large impact on our
understanding of autoimmunity. More than 30 genome-wide association studies
(GWAS) have been published to date in several autoimmune diseases (AID) and ...
H Hakonarson - The Future of Genomic Medicine II The Future of … - stsiweb.org Advances in Understanding Chronic Illness: Pediatric Diseases Hakon Hakonarson,
MD, Ph. D. Director, Center for Applied Genomics Department of Pediatrics &
Division of Genetics The Joseph Stokes Jr. Research Institute The ... Related articles - View as HTML
H Hakonarson, SFA Grant - Seminars in Immunology, 2009 - Elsevier Genome-wide association studies have delivered on the promise of uncovering
genetic determinants of complex disease. In this review, we provide a summary of
recent advances in the identification of multiple variants associated with ... Related articles - All 2 versions
SFA Grant, H Hakonarson - Current Diabetes Reports, 2009 - Springer Type 1 diabetes (T1D) is a chronic disease that typically manifests itself in
childhood through the autoimmune destruction of pancreatic β cells, resulting
in a lack of production of insulin. T1D is a multifactorial disease with a ... Related articles - All 2 versions
Z Wei, W Sun, K Wang, H Hakonarson - Bioinformatics, 2009 - Oxford Univ Press Results: We propose to model the linear block dependency in the SNP data using
hidden Markov models (HMMs). A compound decision–theoretic framework for
testing HMM-dependent hypotheses is developed. We propose a powerful ... Related articles - All 3 versions
HQ Qu, SFA Grant, JP Bradfield, C Kim, E … - British Medical Journal, 2009 - jmg.bmj.com Methods: We analysed data from two sources: (1) The previously published second
stage of our study, with a total sample size of the two stages consisting of
1046 Canadian case–parent trios and 538 multiplex families with 929 ... Related articles - All 3 versions