N Franck - ep.liu.se Obesity has reached epidemic proportions worldwide and is associated with
insulin resistance, type 2 diabetes and cardiovascular disease. During the past
decades, substantial evidence has demonstrated that not only the amount of ... Cited by 1 - Related articles - View as HTML - All 3 versions
M Schreurs, F Kuipers, FR van der Leij - Obesity reviews: an official journal of the International …, 2009 - interscience.wiley.com Insulin sensitizers like metformin generally act through pathways triggered by
adenosine monophosphate-activated protein kinase. Carnitine palmitoyltransferase
1 (CPT1) controls mitochondrial β-oxidation and is inhibited by ... Related articles - All 2 versions
MC Sugden, MG Zariwala, MJ Holness - Pharmacological Research, 2009 - Elsevier This contribution describes recent advances in our knowledge of the regulatory
interactions between the two major oxidative fuels glucose and lipid. It also
addresses how the metabolic abnormalities associated with insulin ... Related articles - All 2 versions
I Pagel-Langenickel, J Bao, L Pang, MN Sack - Endocrine Reviews, 2009 - Endocrine Soc Multiple organs contribute to the development of peripheral insulin resistance,
with the major contributors being skeletal muscle, liver, and adipose tissue.
Because insulin resistance usually precedes the development of type 2 ...
S Beck Jørgensen, HM O'Neill, K Hewitt, BE … - Diabetologia, 2009 - Springer Abstract Aims/hypothesis Obesity-related insulin resistance is associ- ated with
accumulation of bioactive lipids in skeletal muscle. The AMP-activated protein
kinase (AMPK) regulates lipid oxidation in muscle by inhibiting acetyl-CoA ... Related articles - All 2 versions
S Schenk, MP Harber, CR Shrivastava, CF … - The Journal of Physiology, 2009 - Physiological Soc Obesity is characterized by excessive rates of plasma fatty acid mobilization
and uptake, which play a key role in mediating insulin resistance. While weight
loss via diet-only or a diet + exercise program clearly improves insulin ... Related articles - All 5 versions