MV Tzvetkov, SV Vormfelde, D Balen, I … - CliniCal …, 2009 - crosbi.znanstvenici.hr Interindividual variations in the pharmacokinetics of drugs may be caused by genetic variations
in biotransformation and transmembrane transport.1–5 Metformin is a very important oral antidiabetic
drug used in the treatment of type 2 diabetes, and therefore its genetically determined ... Cited by 3 - Related articles - View as HTML - All 8 versions
JC Florez - Journal of Diabetes Science and Technology, 2009 - journalofdst.org Since 2000, we have witnessed an explosion of known genetic determinants of type 2 diabetes
risk. These findings have seeded the expectation that our ability to make personalized,
predictive, therapeutic clinical decisions is imminent. However, the loci discovered to date ... Cited by 1 - Related articles - View as HTML - All 2 versions
O Zolk - Clinical Pharmacology & Therapeutics, 2009 - nature.com The identification of transporters for organic cations involved in the distribution and elimination
of the antidiabetic compound metformin marks a milestone in the study of metformin's
pharmacokinetics. This was followed by the urgent question of whether genetic variations ...
MK Degorter, RB Kim - Hepatology (Baltimore, Md.), 2009 - ncbi.nlm.nih.gov 1: Hepatology. 2009 Aug 10;50(4):1014-1016. [Epub ahead of print]. Hepatic drug
transporters, old and new: Pharmacogenomics, drug response, and clinical relevance.
Degorter MK, Kim RB. Department of Physiology and ... Related articles - All 2 versions
M Tsuda, T Terada, T Mizuno, T Katsura, J Shimakura … - Molecular Pharmacology, 2009 - ASPET Multidrug and toxin extrusion 1 (MATE1/SLC47A1) is important for excretion of organic cations
in the kidney and liver, where it is located on the luminal side. Although its functional and regulatory
characteristics have been clarified, its pharmacokinetic roles in vivo have yet to be ... Cited by 2 - Related articles - All 3 versions
ML Becker, LE Visser, RHN van Schaik, A … - Pharmacogenetics …, 2009 - pdfs.journals.lww.com Objective Metformin is transported into the hepatocyte by organic cation transporter 1
(OCT1) and out of the hepatocyte by multidrug and toxin extrusion 1 (MATE1). Recently, we discovered
that polymorphisms rs622342 A > C in the SLC22A1 gene, coding for OCT1, and ...
[CITATION] Hepatic drug transporters, old and new: Pharmacogenomics, drug response, and …
MK DeGorter, RB Kim - Hepatology, 2009 - Wiley Subscription Services, Inc., A … Related articles
F Giorgino, P Gentili, T Bufacchi, N Visalli, M Agrusta, P … - G It Diabetol Metab, 2009 - gidm.it Si discute da tempo su quale possa essere l'approccio tera- peutico più corretto nei confronti
del paziente con diabete di tipo 2 di recente insorgenza. Certamente, l'approccio globa- le prevede
che venga posta attenzione a vari obiettivi tera- peutici, che includono non solo la ... Related articles - View as HTML - All 2 versions