L Shu, AV Matveyenko, J Kerr-Conte, JH Cho … - Human Molecular Genetics, 2009 - Oxford Univ Press Recent human genetics studies have revealed that common variants of the TCF7L2
(T-cell factor 7-like 2, formerly known as TCF4) gene are strongly associated
with type 2 diabetes mellitus (T2DM). We have shown that TCF7L2 expression ... Cited by 1 - Related articles
S Dabernat, P Secrest, E Peuchant, F Moreau … - Diabetologia, 2009 - Springer Abstract Aims/hypothesis Wingless and iNT-1 (WNT) pathway members are critical
for pancreatic development and exocrine tissue formation. Recently, much
attention has focused on delineating the roles of β-catenin in pancreatic ... Related articles - All 2 versions
ER Pearson - Diabetologia, 2009 - Springer We are living through a revolution in genetics research. At present, barely a
week goes by without a flurry of reports revealing robustly replicated loci
associating with a common complex disease. Diabetes was one of the first ... Related articles - All 2 versions
… , D Moczulski, N Wawrusiewicz-Kurylonek, W … - Acta Diabetologica - Springer Abstract Common polymorphisms in the transcription factor 7-like 2 gene (TCF7L2)
have been associated with type 2 diabetes in different populations and recently
with LADA, but not with type 1 diabetes. The aim of our study was to ... Related articles - All 2 versions
L Groop, V Lyssenko - Diabetes, Obesity and Metabolism, 2009 - interscience.wiley.com Although the genetic causes of monogenic disorders have been successfully
identified in the past, the success in dissecting the genetics of complex
polygenic diseases has until now been limited. With the introduction of ... Related articles - All 3 versions
S Bo, R Gambino, G Ciccone, R Rosato, N … - American Journal of Clinical Nutrition - Am Soc Nutrition ABSTRACT Background: TCF7L2 is the strongest locus linked to type 2 di- abetes
that has been identified thus far, and rs7903146 is the most significantly
associated variant. Few intervention studies have shown that it has ...
I Processing - Am Diabetes Assoc Insulin Processing. Islets were incubated overnight in RPMI 1640 with 11.1 mM
glucose plus 10% fetal bovine serum (FBS) and washed twice in Cys/Met-free
Dulbecco's Modified Eagle Medium (DMEM) containing 25.5mM glucose. The ... Related articles
VA Potapov, DA Chistiakov, MS Shamkhalova … - Diabetes & Metabolic Syndrome: Clinical Research & …, 2009 - Elsevier The allele T of rs12255372 and allele R of rs13266634 showed significant
association with a higher diabetes risk (Odds Ratio (OR) = 1.37 and 1.22,
respectively). Adjustment for confounding risk factors strengthened the ... Related articles