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Scholar Results 1 - 2 of 2 citing Costes: Degradation of cAMP-Responsive Element-Binding Protein by the Ubiquitin-Proteasome.... (0.08 sec) 

ADP receptor P2Y 13 induce apoptosis in pancreatic β-cells


C Tan, A Salehi, S Svensson, B Olde, D Erlinge - Cellular and Molecular Life … - Springer
Abstract Pancreatic b-cell loss represents a key factor in the pathogenesis of diabetes. Since
the influence of puri- nergic signaling in b-cell apoptosis has not been much investigated, we
examined the role of the ADP receptor P2Y13 using the pancreatic insulinoma-cell line ...

Reactive Oxygen Species Decrease cAMP Response Element Binding Protein …


N Ozgen, J Guo, Z Gertsberg, P Danilo Jr, MR Rosen, … - Molecular Pharmacology, 2009 - ASPET
Reactive oxygen species (ROS) exert pleiotropic effects on a wide array of signaling proteins
that regulate cellular growth and apoptosis. This study shows that long-term treatment with a
low concentration of H 2 O 2 leads to the activation of signaling pathways involving ...
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