SE Allan, R Broady, S Gregori, ME Himmel, N … - Immunological …, 2008 - pt.wkhealth.com Acknowledgements: We thank Paul Orban for critical reading of the manuscript. The authors'
own research was supported by grants from the Canadian Institutes for Health Research
(CIHR), the National Cancer Institute of Canada, the Roche Organ Transplant Research ... Cited by 22 - Related articles - All 6 versions
R Spolski, M Kashyap, C Robinson, Z Yu, … - Proceedings of the …, 2008 - National Acad Sciences IL-21 is a pleiotropic type I cytokine that shares the common cytokine receptor γ chain and plays
important roles for normal Ig production, terminal B cell differentiation to plasma cells, and Th17
differentiation. IL-21 is elevated in several autoimmune diseases, and blocking its action ... Cited by 21 - Related articles - All 8 versions
E Jaeckel, N Mpofu, N Saal, MP … - Hormone and Metabolic …, 2008 - thieme-connect.com Beta-cell specific autoreactive T cells can be found in patients with type I diabetes (T1D) and
in healthy controls. They are usually controlled by a network of regulatory mechanisms including
CD4+CD25+Foxp3+ regulatory T cells (Tregs). It was suspected that defects in Treg ... Cited by 9 - Related articles - BL Direct - All 2 versions
- ►pnas.org AM D'Alise, V Auyeung, M Feuerer, J … - Proceedings of the …, 2008 - National Acad Sciences FoxP3 + regulatory T cells (Tregs) protect against autoimmunity, type 1 diabetes (T1D) in
particular, prompting the hypothesis that a deficiency in Tregs is a critical determinant of diabetes
susceptibility in NOD mice. However, tests of this hypothesis have yielded contradictory ... Cited by 9 - Related articles - All 7 versions
SG Zheng - International Journal of Clinical and Experimental …, 2008 - pubmedcentral.nih.gov Foxp3+T regulatory cell (Treg) subsets play a crucial role in the maintenance of immune homeostasis
against self-antigen. The lack or dysfunction of these cells is responsible for the pathogenesis
and development of many autoimmune diseases. Therefore, manipulation of these cells ... Cited by 6 - Related articles - All 5 versions
DB Rainbow, L Esposito, SK Howlett, KM … - Biochemical Society …, 2008 - pubmedcentral.nih.gov The MHC region remains the major genetic determinant causing T1D in humans and NOD mice
[1, 2] and the identification of non-MHC genes contributing T1D susceptibility has made significant
progress. Of particular note, in 2007 it was demonstrated unequivocally that ... Cited by 6 - Related articles - BL Direct - All 9 versions
CA Dendrou, LS Wicker - Journal of Clinical Immunology, 2008 - Springer Abstract Although the interleukin-2 (IL-2)/IL-2R signal- ing pathway has been the focus of numerous
studies, certain aspects of its molecular regulation are not well characterized, especially in
non-T cells, and a more complete understanding of the pathway is necessary to discern ... Cited by 3 - Related articles - All 2 versions
E Sgouroudis, CA Piccirillo - Diabetes/Metabolism Reviews - interscience.wiley.com In recent years, there has been a revival of the concept of CD4 + regulatory T (T reg ) cells as
being a central control point in various immune responses, including autoimmune responses
and immunity to transplants, allergens, tumours and infectious microbes. The current ... Cited by 7 - Related articles - All 2 versions
RR Dietert - Current Drug Safety, 2008 - ingentaconnect.com Abstract: Developmental immunotoxicity (DIT) recently emerged as a significant concern for drug
safety and was the topic of several recent scientific forums in Europe, North America and
Asia. The heightened concern is based on several observations: 1) many childhood ... Cited by 2 - Related articles - All 3 versions
