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Scholar Results 1 - 10 of about 25 citing Tang: Evidence for a role of superoxide generation in glucose-induced β-cell dysfunction in vivo. (0.12 sec) 

Too much of a good thing: why it is bad to stimulate the beta cell to secrete insulin


K Aston-Mourney, J Proietto, G Morahan, S … - Diabetologia, 2008 - Springer
Abstract In many countries, first- or second-line pharma- cological treatment of patients with type
2 diabetes consists of sulfonylureas (such as glibenclamide [known as glyburide in the USA
and Canada]), which stimulate the beta cell to secrete insulin. However, emerging ...
Cited by 12 - Related articles - BL Direct - All 3 versions

The intrauterine metabolic environment modulates the gene expression pattern in …


B Reusens, T Sparre, L Kalbe, T Bouckenooghe, N … - Diabetologia, 2008 - Springer
Abstract Aims/hypothesis Events during fetal life may in critical time windows programme tissue
development leading to organ dysfunction with potentially harmful consequences in adulthood
such as diabetes. In rats, the beta cell mass of progeny from dams fed with a low-protein ...
Cited by 4 - Related articles - BL Direct - All 3 versions

Upregulation of the heme oxygenase system ameliorates postprandial and fasting …


JF Ndisang, N Lane, A Jadhav - American Journal of Physiology- …, 2009 - Am Physiological Soc
In type 2 diabetes (T2D), postprandial and fasting hyperglycemia are important predictors of
cardiovascular diseases; however, few drugs are currently available to simultaneously suppress
these conditions. Here, we report an enduring antidiabetic effect of the heme oxygenase ( ...
Cited by 4 - Related articles - All 4 versions

Heme oxygenase system enhances insulin sensitivity and glucose metabolism in …


JF Ndisang, A Jadhav - American Journal of Physiology- …, 2009 - Am Physiological Soc
Hyperglycemia-induced oxidative stress is a common phenomenon in diabetes. Since oxidative
stress depletes adiponectin and insulin levels, we investigated whether an upregulated heme
oxygenase (HO) system would attenuate the oxidative destruction of adiponectin/insulin ...
Cited by 4 - Related articles - All 3 versions

Up-Regulating the Hemeoxygenase System Enhances Insulin Sensitivity and …


JF Ndisang, A Jadhav - Endocrinology, 2009 - Endocrine Soc
Insulin-mediated signal transduction is positively correlated to adiponectin, adenosine
monophosphate-activated protein kinase (AMPK), and glucose-transporter-4 (GLUT4) but negatively
to oxidative/inflammatory mediators such as nuclear factor- B, activating-protein (AP)-1, ...
Cited by 3 - Related articles - All 3 versions

Anti-oxidized low-density lipoprotein antibody levels are associated with the …


L Garrido-Sánchez, F Cardona, E García- … - European Journal of …, 2008 - pt.wkhealth.com
Results: Of the women who were OGTT-N at the start of the study and who had anti-oxidized
LDL antibody levels below the 50th percentile, only 65·1% were still OGTT-N after 6 years versus
79·5% of those who had anti-oxidized LDL antibody levels above the 50th percentile (P = ...
Cited by 3 - Related articles - All 5 versions

Fetal and neonatal nicotine exposure in Wistar rats causes progressive pancreatic …


JE Bruin, MA Petre, S Raha, KM Morrison, HC … - PLoS ONE, 2008 - pubmedcentral.nih.gov
Nicotine replacement therapy (NRT) is currently recommended as a safe smoking cessation
aid for pregnant women. However, fetal and neonatal nicotine exposure in rats causes
mitochondrial-mediated beta cell apoptosis at weaning, and adult-onset dysglycemia, ...
Cited by 2 - Related articles - All 6 versions

Glucose-modulated tyrosine nitration in beta cells: Targets and consequences

- ccf.org [PDF] 
T Koeck, JA Corbett, JW Crabb, DJ Stuehr, KS … - Archives of Biochemistry …, 2009 - Elsevier
Hyperglycemia, key factor of the pre-diabetic and diabetic pathology, is associated with cellular
oxidative stress that promotes oxidative protein modifications. We report that protein nitration
is responsive to changes in glucose concentrations in islets of Langerhans and ...
Cited by 1 - Related articles - All 6 versions

The Heme Oxygenase System Abates Hyperglycemia in Zucker Diabetic Fatty Rats …


JF Ndisang… - Endocrinology, 2009 - Endocrine Soc
Emerging evidence indicates that aldosterone causes oxidative stress by stimulating
proinflammatory/oxidative mediators, including nuclear factor- B, activating protein (AP-1), and
c-Jun N-terminal kinase. Thus, in insulin-resistant type 2 diabetes (T2D), oxidative stress ...
Cited by 2 - Related articles - All 3 versions

Hypoglycemic and beta cell protective effects of andrographolide analogue for …


Z Zhang, J Jiang, P Yu, X Zeng, JW Larrick, Y … - Journal of Translational …, 2009 - dx.doi.org
In alloxan-treated mice (a model of type 1 diabetes), drugs were administered orally once daily
for 6 days post-alloxan treatment. Fasting blood glucose and serum insulin were
determined. Pathologic and immunohistochemical analysis of pancreatic islets were ...


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