SC Hanley, A Pilotte, B Massie, L Rosenberg - Laboratory Investigation, 2008 - muhc.ca Cultured human islets can be dedifferentiated to duct-like structures composed
mainly of cytokeratinþ and nestinþ cells. Given that these structures possess
the potential to redifferentiate into islet-like structures, we sought to ... Cited by 6 - Related articles - View as HTML - All 5 versions
- ►nih.gov Y Bar, HA Russ, S Knoller, L Ouziel-Yahalom, … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE—In vitro expansion of β-cells from adult human islets could solve
the tissue shortage for cell replacement therapy of diabetes. Culture of human
islet cells typically results in <16 cell doublings and loss of insulin ... Cited by 3 - Related articles - All 4 versions
PM Jones, ML Courtney, CJ Burns, SJ … - Drug discovery today, 2008 - Elsevier In Type 1 diabetes mellitus the insulin-secreting β-cells in pancreatic islets
of Langerhans are selectively destroyed by autoimmune assault. Because diabetes
is caused by the loss of a single cell type it is amenable to treatment by ... Cited by 3 - Related articles - All 3 versions
K Brennand, D Melton - J Cell Mol Med, 2009 - interscience.wiley.com The β-cells of the pancreas are responsible for insulin production and their
destruction results in type I diabetes. β-cell maintenance, growth, and
regenerative repair is thought to occur predominately, if not exclusively, ... Cited by 1 - Related articles - All 3 versions
S Efrat - The Review of Diabetic Studies: RDS, 2008 - pubmedcentral.nih.gov Ex-vivo generation of human insulin-producing cells is considered a promising
approach to providing an abundant source of cells for beta-cell replacement
therapy in diabetes. Expansion of adult beta-cells from the limited number ... Cited by 1 - Related articles - All 3 versions
S Efrat - Diabetologia, 2008 - Springer To the Editor: Expansion of beta cells from isolated adult human islets in
tissue culture represents an attractive potential source of cells for cell
therapy for diabetes. Evidence supports the regeneration of adult mouse ... Cited by 1 - Related articles - BL Direct - All 2 versions
Y Saisho, E Manesso, T Gurlo, C Huang, GM … - American Journal of Physiology- Endocrinology And …, 2009 - Am Physiological Soc An obstacle to development of methods to quantify β-cell turnover from pancreas
tissue is the lack of conversion factors for the frequency of β-cell
replication or apoptosis detected by immunohistochemistry to rates of ... Cited by 1 - Related articles - All 3 versions
HA Russ, P Ravassard, J Kerr-Conte, F Pattou, …, 2009 - pubmedcentral.nih.gov In-vitro expansion of functional beta cells from adult human islets is an
attractive approach for generating an abundant source of cells for beta-cell
replacement therapy of diabetes. Using genetic cell-lineage tracing we have ... Related articles - All 3 versions
KL Seeberger, A Eshpeter, RV Rajotte, GS … - Laboratory Investigation, 2008 - nature.com Pancreatic mesenchymal stem cells (MSCs) may be derived from human -cells
undergoing reversible epithelial–mesenchymal transition (EMT), suggesting that
they could be a potential source of new -cells. In this study we sought to ... Cited by 1 - Related articles - All 3 versions
Y Bar, HA Russ, S Knoller, L Ouziel-Yahalom, … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE—In vitro expansion of -cells from adult human islets could solve the
tissue shortage for cell replacement therapy of diabetes. Culture of human islet
cells typically results in 16 cell doublings and loss of insulin ...
