- ►cell.com H Ounissi-Benkalha, C Polychronakos - Trends in Molecular Medicine, 2008 - Elsevier Susceptibility to type 1 diabetes (T1D) is determined by complex interactions
between several genetic loci and environmental factors. Alleles at the human
leukocyte antigen (HLA) locus explain up to 50% of the familial clustering ... Cited by 13 - Related articles - All 4 versions
- ►nih.gov EE Baschal, GS Eisenbarth - Journal of autoimmunity, 2008 - Elsevier A series of genes and loci influencing the genetic risk of type 1A
(immune-mediated) diabetes are now well characterized. These include genes of
the major histocompatibility complex (MHC), polymorphisms 5′ of the ... Cited by 13 - Related articles - All 3 versions
DB Rainbow, L Esposito, SK Howlett, KM … - Biochemical Society transactions, 2008 - pubmedcentral.nih.gov The MHC region remains the major genetic determinant causing T1D in humans and
NOD mice [1, 2] and the identification of non-MHC genes contributing T1D
susceptibility has made significant progress. Of particular note, in 2007 ... Cited by 6 - Related articles - BL Direct - All 9 versions
- ►diabetesjournals.org V Butty, C Campbell, D Mathis, C Benoist - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE—The unfolding of type 1 diabetes involves a number of steps:
defective immunological tolerance, priming of anti-islet autoimmunity, and
destruction of insulin-producing β-cells. A number of genetic loci ... Cited by 4 - Related articles - All 5 versions
S Caillat-Zucman - Tissue Antigens, 2009 - interscience.wiley.com The association of human leukocyte antigen (HLA) molecules with many autoimmune
diseases has been long known. Yet, the molecular basis for these associations
remains unclear for most of these diseases because of the lack of ... Cited by 4 - Related articles - All 4 versions
- ►diabetesjournals.org P Concannon, WM Chen, C Julier, G Morahan, B … - Diabetes, 2009 - Am Diabetes Assoc RESULTS Significant evidence of linkage to type 1 diabetes was confirmed at the
HLA region on chromosome 6p21.3 (logarithm of odds [LOD] = 213.2). There was
further evidence of linkage to type 1 diabetes on 6q that could not be ... Cited by 3 - Related articles - All 4 versions
- ►solvingdiabetes.org [PDF] M Pietropaolo, JM Surhigh, PW Nelson, GS … - Diabetes, 2008 - Am Diabetes Assoc For nonimmunologists, a daunting and rapidly evolving immunologic vocabulary,
our incomplete understanding of both normal and abnormal immune function, and
multiple interrelated complex immune cellular pathways can be a barrier to ... Cited by 3 - Related articles - All 9 versions
GA Heap, DA van Heel - Human Molecular Genetics, 2009 - Oxford Univ Press Chronic inflammatory diseases have been at the forefront of the new genome-wide
association study era. Conditions such as coeliac disease, type 1 diabetes,
Crohn's disease and ulcerative colitis have all benefited with multiple ... Cited by 2 - Related articles - All 3 versions
M Amills, O Ramírez, A Tomàs, G Obexer-Ruff … - Genes and Immunity, 2008 - nature.com Major histocompatibility complex class II DQA and DQB genes have been shown to
be under positive selection in certain mammalian species but not in others,
fuelling a debate about how their polymorphism has evolved. In this study, ... Cited by 2 - Related articles - All 3 versions
SHS Pearce, TR Merriman - Endocrinology and Metabolism Clinics of North …, 2009 - Elsevier The search for the susceptibility alleles for the complex genetic conditions of
type 1 diabetes and autoimmune thyroid diseases has gained momentum in recent
years. Studies have revealed several novel disease susceptibility alleles ... Cited by 2 - Related articles - All 11 versions
