B Song, D Scheuner, D Ron, S Pennathur, … - The Journal of Clinical Investigation, 2008 - pubmedcentral.nih.gov The progression from insulin resistance to type 2 diabetes is caused by the
failure of pancreatic β cells to produce sufficient levels of insulin to meet
the metabolic demand. Recent studies indicate that nutrient fluctuations ... Cited by 22 - Related articles - All 7 versions
EN Gurzov, F Ortis, L Bakiri, EF Wagner, DL … - PLoS One, 2008 - pubmedcentral.nih.gov Cytokines contribute to pancreatic β-cell apoptosis in type 1 diabetes (T1D) by
modulation of β-cell gene expression networks. The transcription factor
Activator Protein-1 (AP-1) is a key regulator of inflammation and ... Cited by 7 - Related articles - All 7 versions
RL Hull, S Zraika, J Udayasankar, K Aston- … - Diabetologia, 2009 - Springer Abstract Aims/hypothesis Supraphysiological levels of the amyloi- dogenic
peptide human islet amyloid polypeptide have been associated with beta cell
endoplasmic reticulum (ER) stress. However, in human type 2 diabetes, ... Cited by 1 - Related articles - All 2 versions
G Szabadkai, MR Duchen - Apoptosis - Springer Abstract Mitochondrial dysfunction plays a role in the pathogenesis of a wide
range of diseases that involve dis- ordered cellular fuel metabolism and
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JC Jonas, M Bensellam, J Duprez, H Elouil, Y … - Diabetes, Obesity and Metabolism, 2009 - interscience.wiley.com Pancreatic β-cells exposed to high glucose concentrations display altered gene
expression, function, survival and growth that may contribute to the slow
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EN Gurzov, F Ortis, DA Cunha, G Gosset, M Li … - Cell Death & Differentiation, 2009 - nature.com Chronic inflammation and pro-inflammatory cytokines are important mediators of
pancreatic -cell destruction in type 1 diabetes (T1D). We presently show that
the cytokines IL-1 +IFN- and different ER stressors activate the Bcl-2 ... Related articles - All 3 versions
K Maedler, G Dharmadhikari, DM Schumann, J … - Expert Opin. Biol. Ther., 2009 - informahealthcare.com Since having been cloned in 1984, IL-1β has been the subject of over 22,000
citations in Pubmed, among them over 800 reviews. This is because of its
numerous effects. IL-1β is a regulator of the body's inflammatory response ... Related articles - All 6 versions
MF Tonnesen, LG Grunnet, J Friberg, AK … - Endocrinology, 2009 - Endocrine Soc Accumulating evidence suggests that endoplasmic reticulum (ER) stress by
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CJH van der Kallen, MMJ van Greevenbroek, … - Apoptosis - Springer Abstract Diabetes mellitus (DM) is a multifactorial chronic metabolic disease
characterized by hyperglyca- emia. Several different mechanisms have been
implicated in the development of the disease, including endoplasmic ... Related articles - All 2 versions