P Concannon, SS Rich, GT Nepom - New England Journal of Medicine, 2009 - content.nejm.org In 1976, the noted human geneticist James Neel titled a book chapter "Diabetes Mellitus: A Geneticist's
Nightmare." 1 Over the past 30 years, however, the phenotypic and genetic heterogeneity of
diabetes has been painstakingly teased apart to reveal a family of disorders that are all ... Cited by 8 - Related articles - All 2 versions
SE Baranzini - Current Opinion in Immunology, 2009 - Elsevier Modern tools for genetic analysis are producing a large impact on our understanding of
autoimmunity. More than 30 genome-wide association studies (GWAS) have been published
to date in several autoimmune diseases (AID) and hundreds of common variants have ...
H Hakonarson - The Future of Genomic Medicine II The Future of … - stsiweb.org Advances in Understanding Chronic Illness: Pediatric Diseases Hakon Hakonarson, MD,
Ph. D. Director, Center for Applied Genomics Department of Pediatrics & Division of Genetics
The Joseph Stokes Jr. Research Institute The Children's Hospital of Philadelphia ... Related articles - View as HTML
H Hakonarson, SFA Grant - Seminars in Immunology, 2009 - Elsevier Genome-wide association studies have delivered on the promise of uncovering genetic determinants
of complex disease. In this review, we provide a summary of recent advances in the identification
of multiple variants associated with autoimmune-mediated disorders; specifically type 1 ... Related articles - All 2 versions
SFA Grant, H Hakonarson - Current Diabetes Reports, 2009 - Springer Type 1 diabetes (T1D) is a chronic disease that typically manifests itself in childhood through
the autoimmune destruction of pancreatic β cells, resulting in a lack of production of insulin. T1D
is a multifactorial disease with a strong genetic component that is thought to interact with ... Related articles - All 2 versions
Z Wei, W Sun, K Wang, H Hakonarson - Bioinformatics, 2009 - Oxford Univ Press Results: We propose to model the linear block dependency in the SNP data using hidden Markov
models (HMMs). A compound decision–theoretic framework for testing HMM-dependent hypotheses
is developed. We propose a powerful data-driven procedure [pooled local index of ... Related articles - All 3 versions
HQ Qu, SFA Grant, JP Bradfield, C Kim, E … - British Medical …, 2009 - jmg.bmj.com Methods: We analysed data from two sources: (1) The previously published second stage of
our study, with a total sample size of the two stages consisting of 1046 Canadian case–parent
trios and 538 multiplex families with 929 affected offspring from the Type 1 Diabetes ... Related articles - All 3 versions