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Scholar Results 1 - 10 of about 662 citing Brownlee: The pathobiology of diabetic complications. (0.08 sec) 

Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic …


L Monnier, E Mas, C Ginet, F Michel, L Villon, … - Jama, 2006 - Am Med Assoc
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Cited by 353 - Related articles - BL Direct - All 3 versions

Reciprocal relationships between insulin resistance and endothelial dysfunction: …

- ahajournals.org
J Kim, M Montagnani, KK Koh, MJ Quon - Circulation, 2006 - Am Heart Assoc
Endothelial dysfunction contributes to cardiovascular diseases, including
hypertension, atherosclerosis, and coronary artery disease, which are also
characterized by insulin resistance. Insulin resistance is a hallmark of ...
Cited by 316 - Related articles - All 9 versions

Cardiovascular actions of insulin

- endojournals.org
R Muniyappa, M Montagnani, KK Koh, MJ … - Endocrine reviews, 2007 - Endocrine Soc
Insulin has important vascular actions to stimulate production of nitric oxide
from endothelium. This leads to capillary recruitment, vasodilation, increased
blood flow, and subsequent augmentation of glucose disposal in classical ...
Cited by 99 - Related articles - BL Direct - All 5 versions

Glycemic variability: a hemoglobin A1c-independent risk factor for diabetic complications


M Brownlee, IB Hirsch - Jama, 2006 - Am Med Assoc
The timing and frequency of SMBG necessary to optimally minimize glycemic
variability need to be determined by future investigations. Additional work is
needed to determine the best pharmacologic strategies for minimizing ...
Cited by 90 - Related articles - BL Direct - All 3 versions

Patients with type 2 diabetes have normal mitochondrial function in skeletal muscle

- nih.gov
R Boushel, E Gnaiger, P Schjerling, M … - Diabetologia, 2007 - Springer
Abstract Aims/hypothesis Insulin resistance and type 2 diabetes are associated
with mitochondrial dysfunction. The aim of the present study was to test the
hypothesis that oxidative phosphorylation and electron transport capacity ...
Cited by 79 - Related articles - BL Direct - All 9 versions

Hexosamines, insulin resistance, and the complications of diabetes: current status

- physiology.org
MG Buse - American Journal of Physiology- Endocrinology And …, 2006 - Am Physiological Soc
The hexosamine biosynthesis pathway (HBP) is a relatively minor branch of
glycolysis. Fructose 6-phosphate is converted to glucosamine 6-phosphate,
catalyzed by the first and rate-limiting enzyme ...
Cited by 79 - Related articles - BL Direct - All 6 versions

Mitochondrial reactive oxygen species-mediated signaling in endothelial cells

- physiology.org
DX Zhang, DD Gutterman - American Journal of Physiology- Heart and Circulatory …, 2007 - Am Physiological Soc
Once thought of as toxic by-products of cellular metabolism, reactive oxygen
species (ROS) have been implicated in a large variety of cell-signaling
processes. Several enzymatic systems contribute to ROS production in ...
Cited by 60 - Related articles - BL Direct - All 5 versions

Adiponectin Suppression of High-Glucose–Induced Reactive Oxygen Species in Vascular …

- diabetesjournals.org
R Ouedraogo, X Wu, SQ Xu, L Fuchsel, H … - Diabetes, 2006 - Am Diabetes Assoc
Adiponectin is an abundant adipocyte-derived plasma protein with
antiatherosclerotic effects. Vascular signal transduction by adiponectin is
poorly understood and may involve 5′-AMP–activated protein kinase ...
Cited by 56 - Related articles - BL Direct - All 6 versions

Diabetes associated cell stress and dysfunction: role of mitochondrial and non- …

- physoc.org
P Newsholme, EP Haber, SM Hirabara, ELO … - The Journal of Physiology, 2007 - Physiological Soc
It is now widely accepted, given the current weight of experimental evidence,
that reactive oxygen species (ROS) contribute to cell and tissue dysfunction and
damage caused by glucolipotoxicity in diabetes. The source of ROS in the ...
Cited by 60 - Related articles - BL Direct - All 8 versions

Role of mitochondrial dysfunction in insulin resistance

- ahajournals.org
J Kim, Y Wei, JR Sowers - Circulation research, 2008 - Am Heart Assoc
Insulin resistance is characteristic of obesity, type 2 diabetes, and components
of the cardiometabolic syndrome, including hypertension and dyslipidemia, that
collectively contribute to a substantial risk for cardiovascular disease. ...
Cited by 49 - Related articles - All 6 versions


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