H Ji, MR Ramsey, DN Hayes, C Fan, K … - Nature, 2007 - nature.com Germline mutation in serine/threonine kinase 11 (STK11, also called LKB1)
results in Peutz–Jeghers syndrome, characterized by intestinal hamartomas and
increased incidence of epithelial cancers 1 . Although uncommon in most ... Cited by 82 - Related articles - BL Direct - All 5 versions
KM Zbuk, C Eng - Nature Clinical Practice Gastroenterology and …, 2007 - medscape.com The hamartomatous polyposis syndromes are a heterogeneous group of disorders
that share an autosomal-dominant pattern of inheritance and are characterized by
hamartomatous polyps of the gastrointestinal tract. These syndromes include ... Cited by 36 - Related articles - BL Direct - All 6 versions
S Matsumoto, R Iwakawa, K Takahashi, T … - Oncogene, 2007 - nature.com Germline LKB1 mutations cause Peutz–Jeghers syndrome, a hereditary disorder
that predisposes to gastrointestinal hamartomatous polyposis and several types
of malignant tumors. Somatic LKB1 alterations are rare in sporadic cancers, ... Cited by 28 - Related articles - BL Direct - All 3 versions
M Sanchez-Cespedes - Oncogene, 2007 - nature.com Germline LKB1 mutations are responsible for Peutz–Jeghers syndrome (PJS).
Tumors at several locations frequently arise in these patients, confirming that
LKB1 is linked to cancer predisposition and is therefore a bona fide tumor- ... Cited by 27 - Related articles - BL Direct - All 6 versions
AF Hezel, N Bardeesy - Oncogene, 2008 - nature.com Germ line mutations in the LKB1 tumor suppressor gene are associated with the
Peutz–Jeghers polyposis and cancer syndrome. Somatic mutations in Lkb1 are
observed in sporadic pulmonary, pancreatic and biliary cancers and ... Cited by 9 - Related articles - All 4 versions
JP Koivunen, J Kim, J Lee, AM Rogers, JO … - British journal of cancer, 2008 - pubmedcentral.nih.gov Somatic mutations of LKB1 tumour suppressor gene have been detected in human
cancers including non-small cell lung cancer (NSCLC). The relationship between
LKB1 mutations and clinicopathological characteristics and other common ... Cited by 8 - Related articles - All 7 versions
WWJ de Leng, M Jansen, R Carvalho, M Polak … - Clinical genetics, 2007 - pubmedcentral.nih.gov LKB1/STK11 germline inactivations are identified in the majority (66–94%) of
Peutz–Jeghers syndrome (PJS) patients. Therefore, defects inother genes or so
far unidentified ways of LKB1 inactivation may cause PJS. The genes ... Cited by 8 - Related articles - BL Direct - All 6 versions
N Thakur, DN Reddy, GV Rao, P … - BMC medical genetics, 2006 - biomedcentral.com Peutz-Jeghers syndrome (PJS) is a rare multi-organ cancer syndrome and
understanding its genetic basis may help comprehend the molecular mechanism of
familial cancer. A number of germ line mutations in the STK11 gene, ... Cited by 5 - Related articles - Cached - All 11 versions
- ►nih.gov D Calva, JR Howe - Surgical Clinics of North America, 2008 - Elsevier Since the histologic description of the hamartomatous polyp in 1957 by
Horrilleno and colleagues, descriptions have appeared of several different
syndromes with the propensity to develop these polyps in the upper and ... Cited by 5 - Related articles - All 16 versions
- ►oxfordjournals.org JR Pedersen-White, LP Chorich, DP Bick, RJ … - Molecular Human Reproduction, 2008 - Oxford Univ Press Idiopathic hypogonadotropic hypogonadism (IHH) and Kallmann syndrome (KS) are
clinically and genetically heterogeneous disorders caused by a deficiency of
gonadotrophin-releasing hormone (GnRH). Mutations in three genes—KAL1, ... Cited by 5 - Related articles - All 5 versions
