- ►jnsonline.org [PDF] DM Lieberman, DW Laske, PF Morrison, KS … - Journal of neurosurgery, 1995 - thejns.org Many novel experimental therapeutic agents, such as neurotrophic factors, enzymes, biological
modifiers, and genetic vectors, do not readily cross the blood-brain barrier. An effective strategy
to deliver these compounds to the central nervous system is required for their application ... Cited by 221 - Related articles - BL Direct - All 6 versions
WM Pardridge - Journal of Cerebral Blood Flow & Metabolism, 1997 - nature.com Jump to main content; Jump to navigation; nature.com homepage; Publications AZ index;
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Advertisement. Login. Journal of Cerebral Blood Flow & Metabolism homepage ... Cited by 155 - Related articles - BL Direct - All 4 versions
PD Inskip, MS Linet, EF Heineman - Epidemiologic reviews, 1995 - Soc Epidemiolc Res Brain cancer is among the more lethal of adult cancers (1-year relative survival, 52 percent)
(1), and there is concern that incidence might be increasing. Whether incidence rates have, in
fact, increased is a fundamental but still unresolved and controversial is- sue (2-9). ... Cited by 150 - Related articles - BL Direct - All 4 versions
H Widner, P Brundin - Brain research, 1988 - ncbi.nlm.nih.gov 1: Brain Res. 1988 Nov;472(3):287-324. Immunological aspects of grafting in the mammalian
central nervous system. A review and speculative synthesis. Widner H, Brundin P. Department
of Clinical Immunology, Karolinska Institute, Huddinge Hospital, Sweden. ... Cited by 146 - Related articles - All 2 versions
- ►pnas.org [PDF] AG Geiser, JJ Letterio, AB Kulkarni, S … - Proceedings of the …, 1993 - National Acad Sciences Page 1. Proc. Natl. Acad. Sci. USA Vol. 90, pp. 9944-9948, November 1993 Immunology
Transforming growth factor I81 (TGF-f81) controls expression of major histocompatibility genes
in the postnatal mouse: Aberrant histocompatibility antigen expression in the ... Cited by 123 - Related articles - All 9 versions
WM Scheld - Reviews of infectious diseases, 1989 - jstor.org Drug delivery to the central nervous system (CNS) is of vital concern to the therapy for primary
CNS disorders and the development of drug neurotoxicity. The factors influenc- ing drug entry
into the CSF include the status of the blood-brain barrier (BBB) and lipid solubility, ... Cited by 81 - Related articles - All 5 versions
AK Kumagai, JD Foundation - Diabetes Metab Rev, 1999 - interscience.wiley.com Neural tissue is entirely dependent on glucose for normal metabolic activity. Since glucose stores
in the brain and retina are negligible compared to glucose demand, metabolism in these tissues
is dependent upon adequate glucose delivery from the systemic circulation. In the brain, ... Cited by 62 - Related articles - BL Direct - All 6 versions
- ►drugdiscoverytoday.com [PDF] WM Pardridge - Drug discovery today, 2007 - Elsevier The most important factor limiting the development of new drugs for the central nervous system
(CNS) is the blood–brain barrier (BBB). The BBB limits the brain penetration of most CNS drug
candidates. The BBB phenomenon is illustrated by Figure 1a. Radiolabeled histamine, a ... Cited by 57 - Related articles - All 6 versions
