D Le Roith - The New England journal of medicine, 1997 - nejm.highwire.org The three peptide hormones, or growth factors, in the IGF family — insulin, IGF-I, and IGF-II —
have approximately 50 percent of their amino acids in common. Insulin is synthesized in the
beta cells of the pancreas as proinsulin, which is cleaved to form insulin and C peptide. ... Cited by 427 - Related articles - BL Direct - All 18 versions
J Ren, WK Samson, JR Sowers - Journal of molecular and cellular cardiology, 1999 - Elsevier Accumulating evidence has indicated that insulin-like growth factor-1 (IGF-1) plays a specific
role in the intricate cascade of events of cardiovascular function, in addition to its well established
growth-promoting and metabolic effects. IGF-1 is believed to mediate many effects of ... Cited by 167 - Related articles - BL Direct - All 6 versions
- ►cshlp.org AM Fernández, JK Kim, S Yakar, J Dupont, C … - Genes & …, 2001 - genesdev.cshlp.org Peripheral insulin resistance and impaired insulin action are the primary characteristics of type
2 diabetes. The first observable defect in this major disorder occurs in muscle, where glucose
disposal in response to insulin is impaired. We have developed a transgenic mouse with ... Cited by 137 - Related articles - BL Direct - All 5 versions
E Conti, C Carrozza, E Capoluongo, M Volpe, F Crea, … - Circulation, 2004 - Am Heart Assoc The IGF-1 system is dynamic and complex, 1,2 involving at least 6 IGF-1–binding proteins
(IGFBP-1 through -6) and several binding protein–related proteases, 1 including
pregnancy-associated plasma protein-A (PAPP-A). The latter promotes IGF-1 ... Cited by 74 - Related articles - BL Direct - All 6 versions
- ►endojournals.org WL Lee, JW Chen, CT Ting, T Ishiwata, SJ Lin, M Korc, … - Endocrinology, 1999 - Endocrine Soc To investigate how insulin-like growth factor I (IGF-I) modulates cardiovascular function and myocardial
apoptosis in heart failure, the therapeutic effects of IGF-I were determined in a canine model
of dilated cardiomyopathy. The animals were paced at 220 beats/min, and the left ... Cited by 73 - Related articles - BL Direct - All 4 versions
- ►endojournals.org E Wolf, PM Jehle, MM Weber, H Sauerwein, A … - Endocrinology, 1997 - Endocrine Soc Insulin-like growth factor I (IGF-I) has acute insulin-like metabolic effects and long-term anabolic
actions offering a range of important therapeutic applications. To evaluate a system for
large-scale production of this peptide in the mammary glands of transgenic livestock, we ... Cited by 44 - Related articles - BL Direct - All 5 versions
Y Takahashi, H Kadowaki, K Momomura, Y Fukushima, … - Diabetologia, 1997 - Springer Summary We report a homozygous missense muta- tion at position 1092 (substitution of glutamine
for arginine) in the tyrosine kinase domain of the insulin receptor in a patient with leprechaunism
associated with severe insulin resistance and intrauterine growth retardation. ... Cited by 38 - Related articles - BL Direct - All 3 versions
K Berneis, U Keller - Baillière's clinical endocrinology and metabolism, 1996 - Elsevier GH may exert metabolic effects either directly or indirectly through increased production of
IGF-I. GH administration increases circulating IGF-I levels via stimulation of hepatic synthesis
and secretion of IGF-I; it may also enhance local IGF-I synthesis, which exerts paracrine ... Cited by 35 - Related articles - BL Direct - All 4 versions
