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Scholar Results 1 - 10 of about 60 citing Saven: 2-Chlorodeoxyadenosine: a newer purine analog active in the treatment of indolent.... (0.09 sec) 

Coherent view of non-Hodgkin's lymphoma

- ascopubs.org [PDF] 
AC Aisenberg - Journal of Clinical Oncology, 1995 - jco.ascopubs.org
Purpose: Even though non-Hodgkin's lymphoma is alrea-sixth in incidence and
mortality among malig- nant neoplasms (and the incidence was increasing at a
rate of 3% to 4% per year before the advent of AIDS epidemic-associated ...
Cited by 134 - Related articles - BL Direct - All 6 versions

Neurotoxicity of purine analogs: a review

- ascopubs.org [PDF] 
BD Cheson, DA Vena, FM Foss, JM Sorensen - Journal of Clinical Oncology, 1994 - jco.ascopubs.org
Purose: The purine analogs, fludarabine, cladrib- ine, and pentostatin, are
active against a broad spectrum of indolent lymphoid malignancies. They also
have simi- lar toxicities, including myelosuppression, immunosup- pression, ...
Cited by 85 - Related articles - BL Direct - All 6 versions

2-Chlorodeoxyadenosine activity in patients with untreated, indolent non-Hodgkin's …

- hematologylibrary.org [PDF] 
A Saven, S Emanuele, M Kosty, J Koziol, D … - Blood, 1995 - bloodjournal.hematologylibrary.org
. reserved Hematology; all rights Copyright 2007 by The American Society of
Suite 200, Washington DC 20036. semimonthly by the American Society of
Hematology, 1900 M St, NW, Blood (print ISSN 0006-4971, online ISSN ...
Cited by 73 - Related articles - BL Direct - All 4 versions

Metabolism and Actions of 2-Chloro-9-(2-deoxy-2-fluoro-{beta}-D-arabinofuranosyl)- …

- aacrjournals.org [PDF] 
C Xie, W Plunkett - Cancer Research, 1995 - AACR
Cl-F-ara-A by either phosphorolysis or acid hydrolysis, it is nota ble that
2-chloroadenine is much less toxic than 2-fluoroadenine (10). Preclinical
biological experiments showed that Cl-F-ara-A is a potent cytotoxin to ...
Cited by 64 - Related articles - BL Direct - All 3 versions

Differential incorporation of ara-C, gemcitabine, and fludarabine into replicating and …

- bloodjournal.org
H Iwasaki, P Huang, MJ Keating, W Plunkett - Blood, 1997 - Am Soc Hematology
The major actions of nucleoside analogs such as arabinosylcytosine (ara-C) and
fludarabine occurs after their incorporation into DNA, during either replication
or repair synthesis. The metabolic salvage and DNA incorporation of the ...
Cited by 61 - Related articles - BL Direct - All 5 versions

Phase 2 study of rituximab in the treatment of cladribine-failed patients with hairy cell …

- hematologylibrary.org
J Nieva, K Bethel, A Saven - Blood, 2003 - bloodjournal.hematologylibrary.org
Hairy cell leukemia (HCL) is an indolent B-cell neoplasm, strongly expressing
CD20. Despite initial very high response rates following cladribine, many
patients (pts) ultimately relapse. Having relapsed after prior treatment ...
Cited by 60 - Related articles - BL Direct - All 6 versions

Cladribine activity in adult Langerhans-cell histiocytosis

- hematologylibrary.org
A Saven, C Burian - Blood, 1999 - bloodjournal.hematologylibrary.org
Langerhans-cell histiocytosis (LCH) results from the accumulation of tissue
histiocytes derived from the same progenitor cells as monocytes. Because
cladribine is potently toxic to monocytes, we conducted a phase II trial of ...
Cited by 56 - Related articles - BL Direct - All 6 versions

Bolus administration of cladribine in the treatment of Waldenström macroglobulinaemia


ES Liu, C Burian, WE Miller, A Saven - British journal of haematology, 1998 - interscience.wiley.com
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Cited by 44 - Related articles - BL Direct - All 5 versions

2-Chlorodeoxyadenosine-induced complete remissions in Langerhans-cell histiocytosis


A Saven, KA Foon, LD Piro - Annals of internal medicine, 1994 - Am Coll Physicians
Langerhans-cell histiocytosis results from the proliferation and accumulation of
tissue histiocytes, clinically manifested as osteolytic lesions, hypothalamic
insufficiency, and seborrheic and vesiculopustular lesions on the scalp, ...
Cited by 43 - Related articles - All 5 versions

Nucleoside analogues in the therapy of Langerhans cell histiocytosis: a survey of members of …


S Weitzman, AS Wayne, R Arceci, JM Lipton, … - Medical and pediatric oncology, 1999 - interscience.wiley.com
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Cited by 41 - Related articles - BL Direct - All 3 versions


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