M Tsujii, RN DuBois - Cell, 1995 - Elsevier Prostaglandin endoperoxide synthase 2, also referred to as cyclooxygenase 2
(COX-2), is a key enzyme in the conversion of arachidonic acid to prostaglandins
and other eicosanoids. Rat intestinal epithelial (RIE) cells were ... Cited by 1963 - Related articles - BL Direct - All 9 versions
- ►stanford.edu [PDF] G Steinbach, PM Lynch, RKS Phillips, MH … - The New England journal of medicine, 2000 - nejm.highwire.org THE EFFECT OF CELECOXIB, A CYCLOOXYGENASE-2 INHIBITOR, IN FAMILIAL ADENOMATOUS
POLYPOSIS ... G IDEON S TEINBACH , MD, P H .D., P ATRICK M. L YNCH , MD, JD, R
OBIN KS P HILLIPS , MB, BS, ... M ARINA H. W ALLACE , MB, BS, E RNEST H ... Cited by 1649 - Related articles - BL Direct - All 13 versions
- ►166.111.30.161 [PDF] JR Vane, YS Bakhle, RM Botting - Annual review of pharmacology and toxicology, 1998 - Annual Reviews ▪ Abstract Cyclooxygenase (COX), first purified in 1976 and cloned in 1988, is
the key enzyme in the synthesis of prostaglandins (PGs) from arachidonic acid.
In 1991, several laboratories identified a product from a second gene with ... Cited by 1640 - Related articles - BL Direct - All 7 versions
- ►fasebj.org RN Dubois, SB Abramson, L Crofford, RA … - The FASEB Journal, 1998 - FASEB 2 In 1893, German chemist Felix Hoffman, motivated by concern for his father's
severe rheumatoid arthritis, set into motion a commercial process for his
employer, the Bayer Company, to produce a molecule with analgesic activity ... Cited by 1334 - Related articles - BL Direct - All 4 versions
M Tsujii, S Kawano, RN DuBois - Proceedings of the National Academy of Sciences of …, 1997 - National Acad Sciences Recent epidemiologic studies have shown a 40–50% reduction in mortality from
colorectal cancer in individuals who take nonsteroidal antiinflammatory drugs on
a regular basis compared with those not taking these agents. One property ... Cited by 1129 - Related articles - All 8 versions
- ►aacrjournals.org [PDF] H Sano, Y Kawahito, RL Wilder, A Hashiramoto … - Cancer research, 1995 - AACR Kamixyu-kii, Kyoto 602, Japan ÂĄH.S., YK, AH, SM, ... KA, SK, HK, MKI:
Arthritis and Rheumatism Branch, National Institute of Arthritis anil
Musculoskeletal ... Several studies indicate that nonsteroidal anti- ... Cited by 891 - Related articles - BL Direct - All 4 versions
- ►mcgill.ca [PDF] E Giovannucci, KM Egan, DJ Hunter, MJ … - New England Journal of Medicine, 1995 - content.nejm.org Results From 1984 through 1992, we documented 331 new cases of colorectal cancer
during 551,651 person-years of follow-up. Women who consistently took two or
more aspirin tablets per week had no appreciable reduction in the risk of ... Cited by 855 - Related articles - BL Direct - All 13 versions
JA Baron, BF Cole, RS Sandler, RW Haile, D … - The New England journal of medicine, 2003 - nejm.highwire.org Methods We performed a randomized, double-blind trial of aspirin as a
chemopreventive agent against colorectal adenomas. We randomly assigned 1121
patients with a recent history of histologically documented adenomas to ... Cited by 721 - Related articles - BL Direct - All 8 versions
MJ Thun, SJ Henley, C Patrono - JNCI Journal of the National Cancer Institute, 2002 - jnci.oxfordjournals.org Numerous experimental, epidemiologic, and clinical studies suggest that
nonsteroidal anti-inflammatory drugs (NSAIDs), particularly the highly selective
cyclooxygenase (COX)-2 inhibitors, have promise as anticancer agents. ... Cited by 645 - Related articles - BL Direct - All 9 versions
