JH Hoofnagle, AM Di Bisceglie - The New England Journal of …, 1997 - nejm.highwire.org Chronic viral hepatitis is the principal cause of chronic liver disease, cirrhosis, and hepatocellular
carcinoma in the world and now ranks as the chief reason for liver transplantation in adults. 1
, 2 , 3 Of the five known hepatitis viruses, three can cause persistent infection and chronic ... Cited by 861 - Related articles - All 4 versions
P Marcellin, N Boyer, A Gervais, M Martinot, … - Annals of internal …, 1997 - Am Coll Physicians Background: Less than 20% of patients with chronic hepatitis C have a sustained response to
interferon-α therapy. The long-term benefit of interferon-α with regard to hepatic viral clearance
and histologic improvement remains unknown. ... Objective: To determine the long-term ... Cited by 419 - Related articles - BL Direct - All 5 versions
- ►bjmu.edu.cn [PDF] N Boyer, P Marcellin - Journal of Hepatology, 2000 - Elsevier HCV infection is characterized by its propensity to chronicity. Because of its high genetic
variability, HCV has the capability to escape the immune response of the host. HCV is not directly
cytopathic and liver lesions are mainly related to immune-mediated mechanisms, which ... Cited by 146 - Related articles - BL Direct - All 12 versions
MJ Tong, LM Blatt, JG McHutchison, RL Co, A … - Hepatology, 1997 - interscience.wiley.com Patients with chronic hepatitis C (n = 103) were treated for 24 weeks with interferon alfa 2b and
followed up for 24 weeks after cessation of therapy (week 48). When hepatitis C virus (HCV)
RNA at week 48 was used to assess interferon response, 15 (14.6%) were virological ... Cited by 114 - Related articles - BL Direct - All 3 versions
JM Pawlotsky - Hepatology, 2000 - heart-intl.net Research produces highly efficient antiviral drugs. At the same time, viruses develop sophisticated
strategies to evade their actions. Resistance to antiviral therapy has become a major issue in
the management of patients with chronic viral infections. The best known example is ... Cited by 93 - Related articles - View as HTML - BL Direct - All 12 versions
MF Abdelmalek, RJ Firpi, C Soldevila-Pico, AI Reed, … - Hepatology - interscience.wiley.com Recurrent hepatitis C infection is an important cause of progressive fibrosis, cirrhosis, and graft
loss following orthotopic liver transplantation. Treatment for posttransplant recurrence of hepatitis
C with interferon-based therapy is difficult but results in loss of detectable virus in up to ... Cited by 93 - Related articles - All 3 versions
- ►umich.edu [PDF] ASF Lok, NT Gunaratnam - Hepatology, 1997 - deepblue.lib.umich.edu Page 1. Diagnosis of Hepatitis C A NNA SF L OK AND N ARESH T. G UNARATNAM Currently,
the second- and third-generation enzyme immu- infection, assessment of the severity of liver
disease, monitor- noassays (EIA-2 and EIA-3) for hepatitis C virus antibody ... Cited by 86 - Related articles - View as HTML - BL Direct - All 8 versions
- ►t-s-g.com [PDF] P Marcellin, T Asselah, N Boyer, C Treatments, N … - Viral Hepatitis, 2005 - books.google.com Chapter 20 Treatment of chronic hepatitis B Patrick Marcellin, Tarik Asselah, Nathalie Boyer
Introduction Three agents are currently approved for the treatment of chronic hepatitis B:
interferon-alpha (IFN-a), lamivu- dine and adefovir. Each agent has inherent limitations ... Cited by 64 - Related articles - BL Direct - All 13 versions
