- ►annals.org [PDF] RA DeFronzo - Annals of internal medicine, 1999 - Am Coll Physicians Type 2 diabetes mellitus is a chronic metabolic disorder that results from defects in both insulin
secretion and insulin action. An elevated rate of basal hepatic glucose production in the presence
of hyperinsulinemia is the pri- mary cause of fasting hyperglycemia; after a meal, im- ... Cited by 794 - Related articles - BL Direct - All 14 versions
- ►shouxi.net KF Petersen, S Dufour, D Befroy, R Garcia, … - The New England …, 2004 - nejm.highwire.org Methods We performed hyperinsulinemic–euglycemic clamp studies in combination with infusions
of [6,6- 2 H 2 ]glucose in healthy, young, lean, insulin-resistant offspring of patients with type
2 diabetes and insulin-sensitive control subjects matched for age, height, weight, and ... Cited by 793 - Related articles - BL Direct - All 14 versions
- ►pharmyaring.com [PDF] SE Inzucchi - Jama, 2002 - Am Med Assoc Context Care of patients with type 2 diabetes has been revolutionized throughout the past several
years—first, by the realization of the importance of tight glycemic control in forestalling
complications, and second, by the availability of several unique classes of oral ... Cited by 610 - Related articles - BL Direct - All 18 versions
G Boden, GI Shulman - European Journal of Clinical …, 2002 - interscience.wiley.com Plasma free fatty acids (FFA) play important physiological roles in skeletal muscle, heart, liver
and pancreas. However, chronically elevated plasma FFA appear to have pathophysiological
consequences. Elevated FFA concentrations are linked with the onset of peripheral and ... Cited by 490 - Related articles - BL Direct - All 3 versions
AB Mayerson, RS Hundal, S Dufour, V Lebon, D Befroy … - Diabetes, 2002 - Am Diabetes Assoc We examined the effect of three months of rosiglitazone treatment (4 mg bid) on whole-body
insulin sensitivity and in vivo peripheral adipocyte insulin sensitivity as assessed by glycerol
release in microdialysis from subcutaneous fat during a two-step (20 and 120 mU · m −2 · ... Cited by 423 - Related articles - BL Direct - All 4 versions
AA Parulkar, ML Pendergrass, R Granda-Ayala, TR … - Ann Intern Med, 2001 - Am Coll Physicians The thiazolidinediones are a new class of compounds for treat- ment of type 2 diabetes. Troglitazone
became available in the United States in 1997 but was withdrawn from the market in March 2000
because it caused severe idiosyncratic liver injury. Rosiglitazone and pioglitazone have ... Cited by 421 - Related articles - All 4 versions
- ►nih.gov JM Olefsky - Journal of Clinical Investigation, 2000 - Am Soc Clin Investig Insulin resistance is a characteristic feature of most patients with type 2 diabetes mellitus and
is almost a universal finding in type 2 diabetic patients who are overweight (1–3). The presence
of insulin resistance leads to increased β-cell insulin secretion with compensatory ... Cited by 408 - Related articles - BL Direct - All 10 versions
- ►ahajournals.org RE Law, S Goetze, XP Xi, S Jackson, Y Kawano, L … - Circulation, 2000 - Am Heart Assoc From the Department of Medicine (REL, SG, X.-PX, SJ, YK, LD, WPM, WAH); the Division of
Endocrinology, Diabetes, and Hypertension (REL, SG, X.-PX, YK, WPM, WAH); the Division of
Cardiology (SJ, LD); and the Department of Pathology and Laboratory Medicine (MCF), ... Cited by 399 - Related articles - BL Direct - All 5 versions
- ►nih.gov KF Petersen, EA Oral, S Dufour, D Befroy, … - Journal of Clinical …, 2002 - Am Soc Clin Investig Lipodystrophy is a rare disorder that is characterized by selective loss of subcutaneous and visceral
fat and is associated with hypertriglyceridemia, hepatomegaly, and disordered glucose
metabolism. It has recently been shown that chronic leptin treatment ameliorates these ... Cited by 350 - Related articles - BL Direct - All 10 versions
SH Caldwell, EE Hespenheide, JA Redick, JC … - The American journal of …, 2001 - nature.com Troglitazone is a thiazolidinedione and peroxisome proliferator–activated receptor gamma (PPAR
) ligand used to treat diabetes mellitus type II. Because hyperinsulinemia may be a factor in nonalcoholic
steatohepatitis (NASH), we postulated that troglitazone could have beneficial effects in ... Cited by 340 - Related articles - BL Direct - All 7 versions
