- ►shouxi.net R Weinshilboum - New England Journal of Medicine, 2003 - content.nejm.org The promise of pharmacogenetics, the study of the role of inheritance in the
individual variation in drug response, lies in its potential to identify the
right drug and dose for each patient. Even though individual differences in ... Cited by 543 - Related articles - All 7 versions
JA Goldstein - British Journal of Clinical Pharmacology, 2001 - pubmedcentral.nih.gov The human CYP2Cs are an important subfamily of P450 enzymes that metabolize
approximately 20% of clinically used drugs. There are four members of the
subfamily, CYP2C8, CYP2C9, CYP2C19, and CYP2C18. Of these CYP2C8, CYP2C9, ... Cited by 311 - Related articles - BL Direct - All 10 versions
- ►shouxi.net GR Wilkinson - The New England journal of medicine, 2005 - nejm.highwire.org Physicians prescribe drugs on the basis of the characteristics of the
medications and on the probability that reliable and reproducible clinical
effects will result. However, differences in drug response among patients ... Cited by 293 - Related articles - All 21 versions
- ►ujaen.es [PDF] HG Xie, RB Kim, AJJ Wood, CM Stein - Annual Review of Pharmacology and Toxicology, 2001 - Annual Reviews ▪ Abstract Ethnicity is an important demographic variable contributing to
interindividual variability in drug metabolism and response. In this rapidly
expanding research area many genetic factors that account for the effects ... Cited by 284 - Related articles - BL Direct - All 9 versions
- ►fh-bonn-rhein-sieg.de [PDF] WE Evans, JA Johnson - Annual review of genomics and human genetics, 2001 - Annual Reviews ▪ Abstract It is well recognized that most medications exhibit wide
interpatient variability in their efficacy and toxicity. For many medications,
these interindividual differences are due in part to polymorphisms in genes ... Cited by 243 - Related articles - All 16 versions
- ►cell.com M Ingelman-Sundberg - Trends in pharmacological sciences, 2004 - Elsevier The field of cytochrome P450 pharmacogenetics has progressed rapidly during the
past 25 years. All the major human drug-metabolizing P450 enzymes have been
identified and cloned, and the major gene variants that cause ... Cited by 204 - Related articles - All 9 versions
- ►ohsu.edu [PDF] M Eichelbaum, M Ingelman-Sundberg, WE …, 2006 - Annual Reviews Pharmacogenetics deals with inherited differences in the response to drugs. The
best-recognized examples are genetic polymorphisms of drug-metabolizing enzymes,
which affect about 30% of all drugs. Loss of function of thiopurine S- ... Cited by 163 - Related articles - BL Direct - All 7 versions
T Furuta, K Ohashi, K Kosuge, XJ Zhao, M … - Clinical Pharmacology & Therapeutics, 1999 - nature.com Methods: CYP2C19 genotype status for 2 mutations associated with the poor
metabolizer phenotype was determined by a polymerase chain
reaction–restriction fragment length polymorphism method in 16 healthy ... Cited by 160 - Related articles - BL Direct - All 3 versions
AJJ Wood - New England Journal of Medicine, 2001 - content.nejm.org Gambia, in whom polymorphisms in the NRAMP1 gene influence susceptibility to
tuberculosis,9 are ex- amples. But even these cases are complex, since non-
genetic factors also influence the outcome. Among these many factors is ... Cited by 143 - Related articles - BL Direct - All 6 versions
