BJ Lipworth - The Lancet, 2005 - Elsevier Inhibitors of phosphodiesterase type 4 (PDE4) act by increasing intracellular
concentrations of cyclic AMP, which has a broad range of anti-inflammatory
effects on various key effector cells involved in asthma and chronic ... Cited by 167 - Related articles - All 18 versions
ST Holgate - Journal of Allergy and Clinical Immunology, 1999 - Elsevier Asthma is an inflammatory disorder of the airways involving coordinate
up-regulation of T H 2-type cytokines encoded in a cluster on chromosome 5q
31-33 on T cells and inflammatory cells. There is also a requirement for ... Cited by 127 - Related articles - All 6 versions
- ►171.66.122.149 SE Dahlén, K Malmstrom, E Nizankowska, B … - American journal of respiratory and critical care …, 2002 - 171.66.122.149 Leukotriene antagonists block the proinflammatory actions of leukotrienes (LT)
and have been introduced as new treatments for asthma. Conventional therapy with
glucocorticosteroids does not inhibit the biosynthesis of leukotrienes. We ... Cited by 123 - Related articles - BL Direct - All 7 versions
- ►atsjournals.org E LEE, T ROBERTSON, J SMITH, S … - American journal of respiratory and critical care …, 2000 - Am Thoracic Soc Eosinophilia is a feature of airway inflammation associated with asthma.
Leukotriene antagonists provide therapeutic benefit in asthma, but their
potential antiinflammatory actions have not been fully explored. We have ... Cited by 114 - Related articles - BL Direct - All 4 versions
- ►nih.gov CA Mancuso, MGE Peterson, ME Charlson - Journal of general internal medicine, 2000 - Springer OBJECTIVE: To assess the effects of depressive symptoms on asthma patients'
reports of functional status and health- related quality of life. DESIGN:
Cross-sectional study. SETTING: Primary care internal medicine practice at ... Cited by 105 - Related articles - BL Direct - All 6 versions
- ►atsjournals.org H Bisgaard, KG Nielsen - American journal of respiratory and critical care …, 2000 - Am Thoracic Soc We hypothesized that a leukotriene receptor antagonist (LTRA) could provide
bronchoprotection against the cold, dry air-induced response in asthmatic
preschool children. In a randomized, double-blind, placebo-controlled ... Cited by 102 - Related articles - BL Direct - All 5 versions
- ►bmj.com DB Price, D Hernandez, P Magyar, J Fiterman, … - British Medical Journal, 2003 - thorax.bmj.com Results: Both groups showed progressive improvement in several measures of
asthma control compared with baseline. Mean morning peak expiratory flow (AM
PEF) improved similarly in the last 10 weeks of treatment compared with ... Cited by 97 - Related articles - BL Direct - All 6 versions
M Peters-Golden, WR Henderson Jr - The New England journal of medicine, 2007 - nejm.highwire.org Leukotrienes ("leuko," from white blood cells; and "trienes," three conjugated
double bonds) comprise a family of products of the 5-lipoxygenase pathway of
arachidonic acid metabolism. The cysteinyl leukotrienes C 4 , D 4 , and E 4 ... Cited by 98 - Related articles - BL Direct - All 5 versions
