GA FitzGerald, C Patrono - The New England journal of medicine, 2001 - nejm.highwire.org Nonsteroidal antiinflammatory drugs (NSAIDs) are widely used to treat arthritis,
menstrual pain, and headache. Although they are effective, their long-term use
is limited by gastrointestinal effects such as dyspepsia and abdominal pain ... Cited by 970 - Related articles - BL Direct - All 5 versions
RA Gupta, RN DuBois… - Nature Reviews Cancer, 2001 - 166.111.30.161 The current trend in cancer research is rational drug design, which begins with
a molecular target initially identified by the basic scientist. But the idea
that targeted inhibition of the cyclooxygenase-2 pathway might be effective ... Cited by 568 - Related articles - View as HTML - All 8 versions
NJ Talley, NB Vakil, P Moayyedi - Gastroenterology, 2005 - Elsevier Since the publication of the initial technical review on evaluation of dyspepsia
in 1998, 1 test and treat for Helicobacter pylori has become very widely
accepted as the approach of choice in those with chronic dyspepsia but no ... Cited by 484 - Related articles - BL Direct - All 21 versions
- ►bmj.com M Mamdani, PA Rochon, DN Juurlink, A Kopp, … - British Medical Journal, 2002 - bmj.com The adoption of selective COX 2 inhibitors has primarily been driven by the
assertion that these drugs cause fewer gastrointestinal events than do
conventional, non-selective NSAIDs. 6 Use of conventional NSAIDs is ... Cited by 259 - Related articles - BL Direct - All 12 versions
- ►aacrjournals.org Y Sun, XM Tang, E Half, MT Kuo, FA … - Cancer Research, 2002 - AACR The cyclooxygenase-2 (COX-2) gene encodes an inducible enzyme that converts
arachidonic acid to prostaglandins and is up-regulated in colorectal neoplasms.
Evidence indicates that COX-2 may regulate apoptosis and can influence the ... Cited by 174 - Related articles - BL Direct - All 3 versions
JR Laporte, L Ibanez, X Vidal, L Vendrell, R … - Drug Safety, 2004 - ingentaconnect.com 1 Department of Pharmacology, Therapeutics and Toxicology, Universitat Aut`onoma
de Barcelona, Barcelona, Spain 2 Clinical Pharmacology Service, Hospital
Universitari Vall d'Hebron, Catalonia, Spain 3 Servizio di Farmacologia ... Cited by 116 - Related articles - BL Direct - All 7 versions
FA Sinicrope, S Gill - Cancer and Metastasis Reviews, 2004 - Springer Cyclooxygenase-2 (COX-2) is an inducible enzyme that regulates prostaglandin
synthesis and is overexpressed at sites of inflammation and in several
epithelial cancers. Recently, a causal link for COX- 2 in epithelial ... Cited by 81 - Related articles - BL Direct - All 5 versions
JP Case, AJ Baliunas, JA Block - Archives of Internal Medicine, 2003 - archinte.highwire.org Methods This was a randomized, double-blind, placebo-controlled trial of
diclofenac sodium, 75 mg twice daily, vs acetaminophen, 1000 mg 4 times daily,
in 82 subjects with symptomatic OA of the medial knee. Osteoarthritis was ... Cited by 72 - Related articles - BL Direct - All 6 versions
F Celotti, S Laufer - Pharmacological Research, 2001 - Elsevier In this short review we have tried to focus on some new relevant aspects of the
pharmacological control of inflammation. The clinical availability of new drugs
able to produce a selective inhibition of type 2 cyclooxygenase (COX-2), ... Cited by 71 - Related articles - BL Direct - All 3 versions
D Albert, I Zündorf, T Dingermann, WE Müller, … - Biochemical pharmacology, 2002 - Elsevier The acylphloroglucinol derivative hyperforin is the major lipophilic constituent
in the herb Hypericum perforatum (St. John's wort). The aim of the present study
was to investigate if hyperforin as well as extracts of H. perforatum can ... Cited by 64 - Related articles - All 5 versions
