CJ Piyathilake, AR Frost, U Manne, H Weiss, … - Clinical Cancer Research, 2002 - AACR Results and Conclusions: The expression of EGF-r, erbB-2, and TGF-α were
significantly higher in SCC and associated precancerous lesions than in the
normal bronchial epithelium and hyperplastic lesions of noncancer ... Cited by 66 - Related articles - BL Direct - All 4 versions
LR Belur, JL Frandsen, AJ Dupuy, DH Ingbar, … - Molecular Therapy, 2003 - Elsevier Gene transfer to the lung could provide important new treatments for chronic and
acquired lung diseases such as cystic fibrosis, α1-antitrypsin deficiency,
emphysema, and cancer. DNA-mediated gene transfer to the lung has been ... Cited by 56 - Related articles - All 4 versions
DA Dean, D Machado-Aranda, K Blair-Parks, … - Gene Therapy, 2003 - btxonline.com To increase the levels of pulmonary gene transfer by nonviral vectors, we have
adopted electroporation protocols for use in the lung. A volume of 100–200 ml
of purified plasmid DNA suspended in saline was instilled into the lungs of ... Cited by 56 - Related articles - View as HTML - BL Direct - All 7 versions
AA Stecenko, KL Brigham - Gene therapy, 2003 - nature.com Over the 2 years covered here, there has been one clinical study in which a
normal alpha-1 antitrypsin (AAT) gene was delivered to the nasal epithelium of
AAT-deficient subjects using plasmid–liposome complexes; a second study ... Cited by 45 - Related articles - BL Direct - All 4 versions
- ►nih.gov DR Koehler, U Sajjan, YH Chow, B Martin, G … - Proceedings of the National Academy of Sciences of …, 2003 - National Acad Sciences We developed a helper-dependent adenoviral vector for cystic fibrosis lung gene
therapy. The vector expresses cystic fibrosis transmembrane conductance
regulator (Cftr) using control elements from cytokeratin 18. The vector ... Cited by 42 - Related articles - BL Direct - All 10 versions
M Olive, LC Eisenlohr, P Flomenberg - Viral Immunology, 2001 - liebertonline.com Although nearly all adults are seropositive for adenoviruses, little is known
about the cellu- lar immune responses to these ubiquitous pathogens. We have
previously identified aden- ovirus-specific proliferative T-cell responses ... Cited by 37 - Related articles - BL Direct - All 3 versions
G Toietta, DR Koehler, MJ Finegold, B Lee, J … - Molecular Therapy, 2003 - Elsevier Efforts have been made to deliver transgenes to the airway epithelia of
laboratory animals and humans to develop gene therapy for cystic fibrosis. These
investigations have been disappointing due to combinations of transient and ... Cited by 36 - Related articles - BL Direct - All 3 versions
M Brzoska, K Langer, C Coester, S Loitsch, … - Biochemical and Biophysical Research …, 2004 - Elsevier Purpose. Nanoparticles are able to enhance drug or DNA stability for purposes of
optimised deposition to targeted tissues. Surface modifications can mediate drug
targeting. The suitability of nanoparticles synthesised out of porcine ... Cited by 33 - Related articles - All 4 versions
R Wiewrodt, K Amin, M Kiefer, VP Jovanovic, … - Cancer Gene Therapy, 2003 - nature.com The Herpes simplex virus 1 (HSV) thymidine kinase (tk) suicide gene together
with ganciclovir (GCV) have been successfully used for the in vivo treatment of
various solid tumors and for the ablation of unwanted transfused stem cells ... Cited by 30 - Related articles - BL Direct - All 2 versions
