- ►annals.org R Temple, SS Ellenberg - Annals of Internal Medicine, 2000 - Am Coll Physicians In recent years, several authors have argued that placebo-controlled trials are invariably unethical
when known effective therapy is available for the condition being studied, regardless of the condition
or the consequences of deferring treatment. Some have also disputed the value of ... Cited by 396 - Related articles - BL Direct - All 9 versions
- ►zhaoys.com [PDF] HR Black, WJ Elliott, G Granditis, P Grambsch - ACC Current Journal Review, 2003 - Elsevier Methods: A double-blind randomized trial in 16,602 subjects with hypertension and 1 or more
other CV risk factors. The primary end point was a myocardial infarction, stroke or CV death.
The study was designed to last 5 years. Equivalent effectiveness was pre-specified if the ... Cited by 347 - Related articles - BL Direct - All 14 versions
KE Andersson, R Appell, LD Cardozo, C Chapple, HP … - BJU international, 1999 - icsoffice.org Page 1. Committee 10 Pharmacological Treatment of Urinary Incontinence Chairman KE
ANDERSSON (SWEDEN) Members R. APPELL (USA), L. CARDOZO (UK), C. CHAPPLE
(UK), H. DRUTZ (CANADA), J. FOURCROY, O. NISHIZAWA (JAPAN), ... Cited by 238 - Related articles - BL Direct - All 9 versions
EAM Gale - The Lancet, 2001 - Elsevier Troglitazone, the first in the thiazolidinedione class of oral hypoglycaemic agents, was launched
in the USA in March, 1997. It reached Europe later that year, only to be withdrawn within weeks
on the grounds of liver toxicity. Meanwhile it went on to generate sales of over $2 billion in ... Cited by 176 - Related articles - BL Direct - All 5 versions
EJ Emanuel, FG Miller - The New England journal of medicine, 2001 - nejm.highwire.org The first placebo-controlled trial was probably conducted in 1931, when sanocrysin was compared
with distilled water for the treatment of tuberculosis. 1 Ever since then, placebo-controlled trials
have been controversial, especially when patients randomly assigned to receive placebo ... Cited by 164 - Related articles - BL Direct - All 16 versions
RB D'Agostino, JM Massaro, LM Sullivan - Statistics in Medicine, 2002 - haberle.com STATISTICS IN MEDICINE Statist. Med. 2003; 22:169–186 (DOI: 10.1002/sim.1425) ...
Non-inferiority trials: design concepts and issues – the encounters of academic consultants in
statistics ... Ralph B. D'Agostino Sr.1;2;∗;† , Joseph M. Massaro1;2;3 and Lisa M. ... Cited by 131 - Related articles - View as HTML - BL Direct - All 8 versions
FG Gilliam, F Veloso, MAM Bomhof, SK Gazda, V Biton, … - Neurology, 2003 - AAN Enterprises Methods: Adults and children ( 3 years of age) were eligible if the maximum interval since epilepsy
diagnosis was 3 years and patients had one to six partial-onset seizures during a 3-month retrospective
baseline. At study entry, patients (N = 252) were untreated or receiving one antiepileptic ... Cited by 109 - Related articles - BL Direct - All 4 versions
- ►annals.org [PDF] S Kaul, GA Diamond - Annals of internal medicine, 2006 - Am Coll Physicians Active-control noninferiority trials are being performed with increas- ing frequency when standard
placebo-controlled trials are consid- ered unethical. Three attributes are optimally required to
establish noninferiority: 1) The treatment under consideration exhibits ther- apeutic ... Cited by 97 - Related articles - BL Direct - All 6 versions
JL Halperin - American Heart Journal, 2003 - Elsevier SPORTIF III is a randomized, open-label, parallel-group study with blinded event assessment
involving 3407 patients at 259 sites in 23 countries. SPORTIF V is similar, but with double-blind
treatment allocation involving 3922 patients at 409 North American sites. The primary end ... Cited by 91 - Related articles - All 3 versions
M Rothmann, N Li, G Chen, GYH Chi, R Temple, HH … - Statistics in Medicine, 2002 - sctweb.org STATISTICS IN MEDICINE Statist. Med. 2003; 22:239–264 (DOI: 10.1002/sim.1400) ... Design
and analysis of non-inferiority mortality trials in oncology ‡;¶ ... Mark Rothmann1;∗;† , Ning
Li1, Gang Chen1, George YH Chi1, Robert Temple2 and Hsiao-Hui Tsou1 Cited by 85 - Related articles - View as HTML - BL Direct - All 6 versions
