R Jaenisch, A Bird - Nature genetics, 2003 - mozebi.de Cells of a multicellular organism are genetically homogeneous but structurally
and functionally heterogeneous owing to the differential expression of genes.
Many of these differences in gene expression arise during development and ... Cited by 1157 - Related articles - BL Direct - All 12 versions
- ►pnas.org S Friso, SW Choi, D Girelli, JB Mason, GG … - Proceedings of the National Academy of Sciences, 2002 - National Acad Sciences DNA methylation, an essential epigenetic feature of DNA that modulates gene
expression and genomic integrity, is catalyzed by methyltransferases that use
the universal methyl donor S-adenosyl-l-methionine. ... Cited by 373 - Related articles - BL Direct - All 11 versions
- ►hematologylibrary.org - Free from Publisher JPJ Issa, G Garcia-Manero, FJ Giles, R … - Blood, 2004 - bloodjournal.hematologylibrary.org Decitabine (5-aza-2'-deoxycytidine) inhibits DNA methylation and has dual
effects on neoplastic cells, including the reactivation of silenced genes and
differentiation at low doses and cytotoxicity at high doses. We evaluated, ... Cited by 326 - Related articles - BL Direct - All 7 versions
- ►physiology.org SH Itzkowitz, X Yio - American Journal of Physiology- Gastrointestinal and …, 2004 - Am Physiological Soc Patients with ulcerative colitis and Crohn's disease are at increased risk for
developing colorectal cancer. To date, no known genetic basis has been
identified to explain colorectal cancer predisposition in these ... Cited by 275 - Related articles - All 3 versions
- ►ascopubs.org PM Das, R Singal - Journal of Clinical Oncology, 2004 - jco.ascopubs.org DNA methylation is an important regulator of gene transcription, and its role in
carcinogenesis has been a topic of considerable interest in the last few years.
Alterations in DNA methylation are common in a variety of tumors as well as ... Cited by 247 - Related articles - BL Direct - All 7 versions
SB Baylin… - Nature Clinical Practice Oncology, 2005 - interscience.wiley.com It is also possible that your web browser is not configured or not able to
display style sheets. In this case, although the visual presentation will be
degraded, the site should continue to be functional. We recommend using the ... Cited by 189 - Related articles - BL Direct - All 6 versions
- ►hematologylibrary.org H Kantarjian, Y Oki, G Garcia-Manero, X Huang … - Blood, 2007 - bloodjournal.hematologylibrary.org Epigenetic therapy with hypomethylating drugs is now the standard of care in
myelodysplastic syndrome (MDS). Response rates remain low, and mechanism-based
dose optimization has not been reported. We investigated the clinical and ... Cited by 173 - Related articles - BL Direct - All 11 versions
- ►aacrjournals.org PS Yan, CM Chen, H Shi, F Rahmatpanah, … - Cancer Research, 2001 - AACR It is now clear that aberrant DNA methylation observed in cancer cells is not
restricted to a few CpG islands, but affects multiple loci. When this epigenetic
event occurs at the 5'-end of the regulatory region of genes, it is ... Cited by 173 - Related articles - BL Direct - All 5 versions
J Goffin, E Eisenhauer - Annals of Oncology, 2002 - Eur Soc Med Oncology DNA methylation inhibitors have demonstrated the ability to inhibit
hypermethylation, restore suppressor gene expression and exert antitumor effects
in in vitro and in vivo laboratory models. Four inhibitors, which are ... Cited by 170 - Related articles - BL Direct - All 6 versions
- ►nih.gov AS Yang, MRH Estecio, K Doshi, Y Kondo, EH … - Nucleic Acids Research, 2004 - Oxford Univ Press We report a method for studying global DNA methylation based on using bisulfite
treatment of DNA and simultaneous PCR of multiple DNA repetitive elements, such
as Alu elements and long interspersed nucleotide elements (LINE). The PCR ... Cited by 165 - Related articles - BL Direct - All 8 versions
