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Scholar Results 1 - 10 of about 122 citing Kurzrock: Philadelphia chromosome-positive leukemias: from basic mechanisms to molecular.... (0.07 sec) 

[PDF] Lessons from natural molecules


J Clardy, C Walsh - Nature, 2004 - openwetware.org
Natural products have inspired chemists and physicians for millennia. Their rich
structural diversity and complexity has prompted synthetic chemists to produce
them in the laboratory, often with therapeutic applications in mind, and ...
Cited by 182 - Related articles - View as HTML - BL Direct - All 22 versions

Genetic factors in aminoglycoside toxicity


N Fischel-Ghodsian - Pharmacogenomics, 2005 - Future Medicine
Ototoxicity is the major irreversible toxicity of aminoglycosides, and it occurs
both in a dose-dependent and idiosyncratic fashion. The idiosyncratic pathway is
presumably due to genetic predispositions, and an inherited mutation in the ...
Cited by 100 - Related articles - BL Direct - All 9 versions

Absolute values of immunoglobulin free light chains are prognostic in patients with primary …

- hematologylibrary.org [PDF] 
A Dispenzieri, MQ Lacy, JA Katzmann, SV … - Blood, 2006 - bloodjournal.hematologylibrary.org
. Hematology; all rights reserved Copyright 2007 by The American Society of DC
20036. by the American Society of Hematology, 1900 M St, NW, Suite 200,
Washington Blood (print ISSN 0006-4971, online ISSN 1528-0020), is ...
Cited by 78 - Related articles - BL Direct - All 9 versions

Renal cell carcinoma: review of novel single-agent therapeutics and combination regimens

- oxfordjournals.org
RJ Amato - Annals of oncology, 2005 - Eur Soc Med Oncology
A search of the Medline database and ASCO 2003 conference proceedings was
conducted to identify clinical trials currently underway using single-agent
therapy for renal cell carcinoma (RCC). Combination trials were identified ...
Cited by 69 - Related articles - All 8 versions

BCR/ABL kinase induces self-mutagenesis via reactive oxygen species to encode imatinib …

- hematologylibrary.org
M Koptyra, R Falinski, MO Nowicki, T Stoklosa … - Blood, 2006 - bloodjournal.hematologylibrary.org
BCR/ABL kinase mutations appear to be the most frequent cause of acquired
resistance to IM; resistant cells also may exhibit genomic amplification of
nonmutated BCR/ABL and BCR/ABL independence due to overexpression of LYN ...
Cited by 64 - Related articles - BL Direct - All 6 versions

[BOOK] Clinical genetics in nursing practice


FR Lashley, 2005 - books.google.com
S^^ 1 Felissa R. Lashley, RN, PhD, FAAN, FACMG (formerly Felissa L. Cohen), is
^1 ^^ I Dean and Professor of the College of Nursing at Rutgers, The State
University ^L 1 of New Jersey. Prior to that she was Dean and Professor of ...
Cited by 56 - Related articles - BL Direct - All 5 versions

STI-571: an anticancer protein-tyrosine kinase inhibitor

- brimr.org [PDF] 
R Roskoski - Biochemical and Biophysical Research …, 2003 - Elsevier
STI-571 (imatinib, Gleevec, Glivec, CGP 57148) is an inhibitor of the Abl group
of protein-tyrosine kinases. One of these enzymes, the Bcr-Abl oncoprotein,
results from the fusion of the BCR and ABL genes that result from the ...
Cited by 56 - Related articles - All 11 versions

A prototype antibody microarray platform to monitor changes in protein tyrosine …

- mcponline.org
DS Gembitsky, K Lawlor, A Jacovina, M … - Molecular & Cellular Proteomics, 2004 - ASBMB
Reversible protein phosphorylation is a key regulatory process in all living
cells. Deregulation of modification control mechanisms, especially in the case
of tyrosine, may lead to malignant transformation and disease. ...
Cited by 54 - Related articles - BL Direct - All 3 versions

Cancer proteomics: serum diagnostics for tumor marker discovery


AJ Rai, DW Chan - ANNALS-NEW YORK ACADEMY OF SCIENCES, 2004 - interscience.wiley.com
Abstract: Cancer proteomics is an exciting field that is witnessing many new
developments in recent years. It is hoped that these advances will result in
decreased cancer death rates, which have not declined dramatically in the ...
Cited by 50 - Related articles - BL Direct - All 5 versions

Bcl-2 phosphorylation and apoptosis activated by damaged microtubules require mTOR and …


L Asnaghi, A Calastretti, A Bevilacqua, I D' … - Oncogene, 2004 - nature.com
The serine/threonine kinase mTOR, the major sensor of cell growth along the
PI3K/Akt pathway, can be activated by agents acting on microtubules. Damaged
microtubules induce phosphorylation of the Bcl-2 protein and lower the ...
Cited by 43 - Related articles - BL Direct - All 5 versions


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