- ►sciencesignaling.org TM Dawson, VL Dawson - Science Signaling, 2003 - stkemag.highwire.org Abstract: Parkinson's disease (PD) is a complex disorder with many different
causes, yet they may intersect in common pathways, raising the possibility that
neuroprotective agents may have broad applicability in the treatment of PD. ... Cited by 644 - Related articles - BL Direct - All 15 versions
- ►jneurosci.org KL Lim, K Chew, JMM Tan, C Wang, KKK … - Journal of Neuroscience, 2005 - Soc Neuroscience It is widely accepted that the familial Parkinson's disease (PD)-linked gene
product, parkin, functions as a ubiquitin ligase involved in protein turnover
via the ubiquitin-proteasome system. Substrates ubiquitinated by parkin are ... Cited by 109 - Related articles - All 6 versions
- ►hamilton.edu [PDF] E Gaggelli, H Kozlowski, D Valensin, G … - Chem. Rev, 2006 - pubs.acs.org Gianni Valensin (born 1946) received his degree in Chemistry from the University
of Florence, Italy, in 1970. He was appointed Full Professor of Physical
Chemistry in 1986 at the University of Basilicata, Italy, and, later, Full ... Cited by 105 - Related articles - All 8 versions
- ►fasebj.org A Recchia, P Debetto, A Negro, D GUIDOLIN … - The FASEB Journal, 2004 - FASEB Alpha-synuclein ( -syn) is a small soluble protein expressed primarily at
presynaptic terminals in the central nervous system. Interest in -syn has
increased dramatically after the discovery of a relationship between its ... Cited by 65 - Related articles - BL Direct - All 3 versions
- ►oxfordjournals.org SR Sriram, X Li, HS Ko, KKK Chung, E Wong … - Human Molecular Genetics, 2005 - Oxford Univ Press Mutations in parkin are largely associated with autosomal recessive juvenile
parkinsonism. The underlying mechanism of pathogenesis in parkin-associated
Parkinson's disease (PD) is thought to be due to the loss of parkin's E3 ... Cited by 62 - Related articles - BL Direct - All 7 versions
PJ Landrigan, B Sonawane, RN Butler, L … - Environmental health perspectives, 2005 - pubmedcentral.nih.gov Parkinson disease (PD) and Alzheimer disease (AD), the two most common
neurodegenerative disorders in American adults, are of purely genetic origin in
a minority of cases and appear in most instances to arise through ... Cited by 61 - Related articles - BL Direct - All 17 versions
M Hsu, B Srinivas, J Kumar, R Subramanian, … - Journal of neurochemistry, 2005 - interscience.wiley.com An early biochemical change in the Parkinsonian substantia nigra (SN) is
reduction in total glutathione (GSH + GSSG) levels in affected dopaminergic
neurons prior to depletion in mitochondrial complex I activity, dopamine ... Cited by 48 - Related articles - All 4 versions
C Wang, JMM Tan, MWL Ho, N Zaiden, SH … - Journal of neurochemistry, 2005 - interscience.wiley.com Mutations in the parkin gene, which encodes a ubiquitin ligase, are currently
recognized as the main contributor to familial forms of Parkinson's disease
(PD). A simple assumption about the effects of PD-linked mutations in ... Cited by 48 - Related articles - All 5 versions
F Schlachetzki, Y Zhang, RJ Boado, WM … - Neurology, 2004 - AAN Enterprises Many chronic neurologic diseases do not respond to small molecule therapeutics,
and have no effective long-term therapy. Gene therapy offers the promise of an
effective cure for both genetic and acquired brain disease. However, the ... Cited by 39 - Related articles - BL Direct - All 4 versions
X Zhang, W Xie, S Qu, T Pan, X Wang, W Le - Biochemical and Biophysical Research …, 2005 - Elsevier The cause of the neurodegenerative process in Parkinson's disease (PD) remains
unclear, but evidence suggests that failure of the ubiquitin–proteasome system
may play a major role in the pathogenesis of the disease. Iron is believed ... Cited by 30 - Related articles - All 4 versions
