- ►yorku.ca [PDF] MP Mattson - Nature, 2004 - nature.com APP is widely expressed in cells throughout the body where the amount produced
is influenced by the developmental and physiological state of the cells. APP is
an integral membrane protein with a single membrane-spanning domain, a ... Cited by 635 - Related articles - BL Direct - All 16 versions
- ►cell.com L Guarente, F Picard - Cell, 2005 - Elsevier A nutritious diet low in calories improves the health and extends the life span
of rodents. Recent studies identified a gene, SIR2, which encodes an
NAD-dependent deacetylase and may mediate the effects of calorie ... Cited by 243 - Related articles - All 19 versions
- ►iastate.edu [PDF] MP Mattson, S Maudsley, B Martin - TRENDS in Neurosciences, 2004 - Elsevier Brain-derived neurotrophic factor (BDNF) and serotonin (5-hydroxytryptamine,
5-HT) are known to regulate synaptic plasticity, neurogenesis and neuronal
survival in the adult brain. These two signals co-regulate one another such ... Cited by 162 - Related articles - All 5 versions
NV Patel, MN Gordon, KE Connor, RA Good, … - Neurobiology of aging, 2005 - Elsevier Dietary influences on Alzheimer disease (AD) are gaining recognition. Because
many aging processes are attenuated in laboratory mammals by caloric restriction
(CR), we examined the effects of short-term CR in two AD-transgenic mice, ... Cited by 82 - Related articles - All 11 versions
MP Mattson, NJ Haughey, A Nath - Cell death and differentiation, 2005 - neuroscience.jhu.edu Many patients infected with human immunodeficiency virus type-1 (HIV-1) suffer
cognitive impairment ranging from mild to severe (HIV dementia), which may
result from neuronal death in the basal ganglia, cerebral cortex and ... Cited by 78 - Related articles - View as HTML - All 5 versions
MP Mattson, R Wan - The Journal of nutritional biochemistry, 2005 - Elsevier Intermittent fasting (IF; reduced meal frequency) and caloric restriction (CR)
extend lifespan and increase resistance to age-related diseases in rodents and
monkeys and improve the health of overweight humans. Both IF and CR enhance ... Cited by 67 - Related articles - All 11 versions
- ►jlr.org RM Lane, MR Farlow - The Journal of Lipid Research, 2005 - ASBMB Extracellular amyloid plaques, intracellular neurofibrillary tangles, and loss
of basal forebrain cholinergic neurons in the brains of Alzheimer's disease (AD)
patients may be the end result of abnormalities in lipid metabolism and ... Cited by 59 - Related articles - All 5 versions
- ►voeljemens.nl [PDF] MP Mattson, 2005 - Annual Reviews ▪ Abstract The size and frequency of meals are fundamental aspects of
nutrition that can have profound effects on the health and longevity of
laboratory animals. In humans, excessive energy intake is associated with ... Cited by 55 - Related articles - BL Direct - All 5 versions
S Kawanishi, S Oikawa - ANNALS-NEW YORK ACADEMY OF SCIENCES, 2004 - interscience.wiley.com Abstract: We investigated whether oxidative stress, which contributes to aging,
accelerates the telomere shortening in human cultured cells. The terminal
restriction fragment (TRF) from WI-38 fibroblasts irradiated with UVA ... Cited by 49 - Related articles - BL Direct - All 5 versions
E Sontag, C Hladik, L Montgomery, A … - Journal of Neuropathology & Experimental Neurology, 2004 - journals.lww.com ABαC, a major protein phosphatase 2A (PP2A) heterotrimeric enzyme, binds to and
regulates the microtubule cytoskeleton and tau. We have shown that ABαC protein
expression levels are selectively reduced in Alzheimer disease (AD). ... Cited by 41 - Related articles - BL Direct - All 3 versions
