MA Atkinson, GS Eisenbarth - The Lancet, 2001 - Elsevier As our knowledge of type 1 (insulin-dependent) diabetes increases, so does our
appreciation for the pathogenic complexity of this disease and the challenges
associated with its treatment. Many new concepts about the pathogenesis of ... Cited by 568 - Related articles - BL Direct - All 15 versions
- ►nih.gov P Achenbach, K Koczwara, A Knopff, H Naserke … - Journal of Clinical Investigation, 2004 - Am Soc Clin Investig Children at risk for type 1 diabetes can develop early insulin autoantibodies
(IAAs). Many, but not all, of these children subsequently develop multiple islet
autoantibodies and diabetes. To determine whether disease progression is ... Cited by 66 - Related articles - BL Direct - All 10 versions
- ►diabetesjournals.org P Achenbach, E Bonifacio, K Koczwara, AG … - Diabetes, 2005 - Am Diabetes Assoc The natural history of autoimmune type 1 diabetes in children is associated with
the appearance of islet autoantibodies early in life, which is influenced by
genetic and environmental factors. Once islet autoantibodies have ... Cited by 37 - Related articles - BL Direct - All 9 versions
M Schlosser, K Koczwara, H Kenk, M … - Diabetologia, 2005 - Springer Abstract Aims/hypothesis: Insulin autoantibodies (IAA) precede and predict the
onset of type 1 diabetes, but not all children with IAA develop the disease. In
affected families, IAA affinity can identify IAA-positive children who are ... Cited by 19 - Related articles - BL Direct - All 3 versions
P Achenbach, E Bonifacio, AG Ziegler - Current Diabetes Reports, 2005 - Springer Introduction Accurate estimation of the risk for developing type 1 diabetes
mellitus (T1DM) is important for the identification of indi- viduals who may
benefit from inclusion in interventional trials aiming to prevent the onset ... Cited by 17 - Related articles - All 2 versions
JM Jasinski, GS Eisenbarth - Clinical & Developmental Immunology, 2005 - hindawi.com Page 1. Insulin as a primary autoantigen for type 1A diabetes JM JASINSKI
1,2,† , & GS EISENBARTH 2,3 1 Human Medical Genetics ... Cited by 15 - Related articles - View as HTML - BL Direct - All 10 versions
- ►pubget.com [PDF] P Achenbach, K Warncke, J Reiter, AJK … - Diabetologia, 2006 - Springer Abstract Aims/hypothesis Combinations of autoantibody character- istics,
including antibody number, titre, subclass and epitope have been shown to
stratify type 1 diabetes risk in islet autoantibody-positive relatives. The ... Cited by 15 - Related articles - BL Direct - All 6 versions
A Casu, M Trucco, M Pietropaolo - The Pediatric Clinics of North America, 2005 - Elsevier Type 1 diabetes mellitus (T1DM) is characterized by the almost complete absence
of insulin secretion, which is secondary to an autoimmune destruction or
dysfunction of the insulin-producing cells of the pancreatic islets of ... Cited by 10 - Related articles - All 16 versions
- Free from Publisher M Huppmann, A Baumgarten, AG Ziegler, E … - Diabetes care, 2005 - Am Diabetes Assoc Type 1 diabetes is a genetic disorder that is associated with the early
development of autoimmunity against islet ß-cells (1). The a priori genetically
determined risk for type 1 diabetes is modified by mostly unknown ... Cited by 8 - Related articles - All 5 versions
- ►shouxi.net A Mayr, M Schlosser, N Grober, H Kenk, AG … - Diabetes, 2007 - Am Diabetes Assoc RESULTS—At first GADA appearance, affinity ranged from 10 7 to 10 10 l/mol.
Affinity was higher in multiple islet autoantibody-positive children (P <
0.0001) and in HLA DR3–positive children (P = 0.006). GADA affinities ... Cited by 8 - Related articles - BL Direct - All 5 versions
