RS Ajioka, JD Phillips, JP Kushner - BBA-Molecular Cell Research, 2006 - Elsevier Most iron in mammalian systems is routed to mitochondria to serve as a substrate
for ferrochelatase. Ferrochelatase inserts iron into protoporphyrin IX to form
heme which is incorporated into hemoglobin and cytochromes, the dominant ... Cited by 36 - Related articles - All 4 versions
- ►nih.gov I Nakamichi, A Habtezion, B Zhong, CH … - Journal of Clinical Investigation, 2005 - Am Soc Clin Investig Hemin upregulates heme oxygenase-1 (HO-1), a stress-induced enzyme implicated in
protection from a variety of injuries while its related isoform HO-2 is
constitutively expressed. The role of hemin or HO-1 in the pancreas and ... Cited by 20 - Related articles - BL Direct - All 10 versions
- ►jimmunol.org K Devadas, S Dhawan - The Journal of Immunology, 2006 - Am Assoc Immnol Hemin, a critical component of hemoglobin, is an active ingredient of a biologic
therapeutic approved by the Food and Drug Administration for the treatment of
acute porphyries. This report describes a biological function of this ... Cited by 16 - Related articles - BL Direct - All 5 versions
KE Anderson, S Collins - The American Journal of Medicine, 2006 - Elsevier Hemin was administered to 111 patients for treatment of 305 acute attacks and to
40 patients for prophylaxis (usually by weekly or biweekly infusions).
Diagnostic laboratory findings reported for 69 patients were confirmatory ... Cited by 11 - Related articles - All 9 versions
AK Seth, MN Badminton, D Mirza, S Russell, E … - Hepatology - interscience.wiley.com Porphyrias are a heterogenous group of diseases that may result in disabling or
life threatening neurovisceral symptoms and/or cutaneous photosensitivity. In
acute intermittent porphyria, the clinical features, particularly ... Cited by 10 - Related articles - BL Direct - All 2 versions
P Poblete-Gutiérrez, T Wiederholt, HF Merk, J … - Eur J Dermatol, 2006 - john-libbey-eurotext.fr There are three ways to classify the different types of porphyrias.
Historically, these disorders have been mostly subdivided into erythropoietic
and hepatic forms, according to the major site of expression of the ... Cited by 9 - Related articles - All 4 versions
- ►clinchem.org AK Aarsand, PH Petersen, S Sandberg - Clinical Chemistry, 2006 - Am Assoc Clin Chem Background: Diagnosis of an attack of acute intermittent porphyria (AIP) is
based on the demonstration of increased concentrations of porphobilinogen (PBG)
and -aminolevulinic acid (ALA) in urine, but many AIP patients also have ... Cited by 9 - Related articles - All 3 versions
BUK Li, F Lefevre, GG Chelimsky, RG Boles, … - Journal of Pediatric Gastroenterology and Nutrition, 2008 - journals.lww.com ÃMedical College of Wisconsin, Milwaukee, {Northwestern University, {Case
Western Reserve University, Cleveland, OH, §Children's Hospital of Los Angeles,
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- ►aspetjournals.org M Liao, MK Pabarcus, YQ Wang, C Hefner, DA … - Journal of Pharmacology and Experimental …, 2007 - ASPET Tryptophan 2,3-dioxygenase (TDO), a liver-specific cytosolic hemoprotein, is the
rate-limiting enzyme in L-tryptophan catabolism and thus a key serotonergic
determinant. Glucocorticoids transcriptionally activate the TDO gene with ... Cited by 5 - Related articles - All 3 versions
