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Scholar Results 1 - 10 of about 34 citing Mueller: Ethical issues in stopping randomized trials early because of apparent benefit. (0.10 sec) 

[BOOK] Information retrieval: a health and biomedical perspective


WR Hersh - 2008 - books.google.com
William Hersh, MD Professor and Chair Department of Medical Informatics & Clinical Epidemiology
Oregon Health & Science University 3181 SW Sam Jackson Park Rd. BICC Portland, OR, USA 97239 Series
Editors Marion J. Ball, Ed.D ...
Cited by 102 - Related articles - All 5 versions

Early stopping of randomized clinical trials for overt efficacy is problematic

- ceb-institute.org [PDF] 
D Bassler, VM Montori, M Briel, P Glasziou, G … - Journal of Clinical …, 2008 - Elsevier
The best strategy to minimize the problems associated with early stopping of RCTs for benefit is not
to stop early. As an alternative, we suggest a threefold approach: a low P-value as the threshold
for stopping at the time of interim ...
Cited by 24 - Related articles - All 13 versions

Stopping at nothing? Some dilemmas of data monitoring in clinical trials

- annals.org
SN Goodman - Annals of Internal Medicine, 2007 - Am Coll Physicians
This commentary reviews the argument that clinical trials with data monitoring committees that use
statistical stopping guidelines should generally not be stopped early for large observed efficacy
differences because efficacy ...
Cited by 20 - Related articles - BL Direct - All 3 versions

Design, conduct, analysis and reporting of a multi-national placebo-controlled trial …

- drugwonks.com [PDF] 
S Finfer, VM Ranieri, BT Thompson, PS Barie, JF … - Intensive care medicine, 2008 - Springer
Received: 14 December 2007 Accepted: 19 August 2008 Published online: 7 October 2008 Ó
Springer-Verlag 2008 ... Electronic supplementary material The online version of this article
(doi:10.1007/s00134-008-1266-6) ...
Cited by 17 - Related articles - All 7 versions

Endarterectomy vs stenting for carotid artery stenosis: a systematic review and …

- endovasc.org [PDF] 
MH Murad, DN Flynn, MB Elamin, GH Guyatt, RW … - Journal of Vascular …, 2008 - Elsevier
Ten RCTs with 3182 participants proved eligible. At 30 days and compared with endarterectomy,
carotid stenting was associated with a nonsignificant reduction in the risk of death (relative risk
[RR], 0.61; 95% confidence interval ...
Cited by 15 - Related articles - All 11 versions

Highly active antiretroviral therapy and the incidence of non-AIDS-defining cancers …

- ascopubs.org [PDF] 
T Powles, D Robinson, J Stebbing, J … - Journal of Clinical …, 2008 - jco.ascopubs.org
Eray Goekkurt, Salah-Eddin Al-Batran, Jörg T. Hartmann, Ulrike Mogck, Gunter Schuch, Michael
Kramer, Elke Jaeger, Carsten Bokemeyer, Gerhard Ehninger, and Jan Stoehlmacher From the Department
of Internal Medi- cine I, ...
Cited by 13 - Related articles - All 4 versions

[PDF] Pro/con debate: Is intensive insulin therapy targeting tight blood glucose control of …


TM Merz, S Finfer - Crit Care, 2008 - biomedcentral.com
You have decided to develop a protocol for insulin therapy in your intensive care unit (ICU). You
wonder about the merit of using intensive insulin therapy (IIT) to maintain tight blood glucose
control in your patients.
Cited by 9 - Related articles - View as HTML - All 7 versions

In the era of systematic reviews, does the size of an individual trial still matter


GH Guyatt, EJ Mills, D Elbourne - PLoS Med, 2008 - medicine.plosjournals.org
Systematic reviews that combine high-quality evidence from several trials are now widely considered
to be at the top of the hierarchy of clinical evidence. Given the primacy of systematic
reviews—and the fact that ...
Cited by 8 - Related articles - Cached - All 11 versions

Denosumab for prevention of fractures in postmenopausal women with …

- ammom.com.mx [PDF] 
SR Cummings, JS Martin, MR McClung, ES … - New England Journal …, 2009 - content.nejm.org
From the San Francisco Coordinating Center, California Pacific Medical Center Research Institute and
University of Cali- fornia, San Francisco, San Francisco (SRC); Amgen, Thousand Oaks, CA (JSM, HBZ,
MA, AW, CL, SS); Oregon ...
Cited by 7 - Related articles - All 14 versions

Stopping or reporting early for positive results in randomized clinical trials: The …

- ascopubs.org [PDF] 
EL Korn, B Freidlin, M Mooney - Journal of Clinical Oncology, 2009 - jco.ascopubs.org
Edward L. Korn, Boris Freidlin, and Margaret Mooney From the Biometric Research Branch and the
Clinical Investigations Branch, Cancer Therapy Evaluation Program, Division of Cancer Treatment and
Diag- nosis, National Cancer ...
Cited by 6 - Related articles - All 6 versions


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