PJ BARNES, S PEDERSEN, WW BUSSE - American Journal of …, 1998 - Am Thoracic Soc Inhaled corticosteroids have revolutionized the treatment of asthma and have now become the
mainstay of therapy for patients with chronic disease (1). In a supplement to this journal published
5 yr ago the currently available data on efficacy and safety of inhaled corticosteroids was ... Cited by 593 - Related articles - All 6 versions
E Frigas, GJ Gleich - Journal of allergy and clinical immunology, 1986 - Elsevier Eosinophilia of lung and blood associated with injury to the mucociliary escalator and excessive
shedding of bronchial epithelium are hallmarks of both allergic and nonallergic asthma. In
vitro, the eosinophil granule major basic protein (MBP) is toxic to helminths and to ... Cited by 365 - Related articles - All 3 versions
- ►canadianmedicaljournal.ca LP Boulet, A Becker, D Berube, R … - Canadian Medical …, 1999 - canadianmedicaljournal.ca *Chair of the editorial committee, Centre de pneumologie, Institut de cardiologie et de pneumologie
de l'Université Laval, Hôpital Laval, Sainte-Foy, Que.; Department of Pediatrics, University of
Manitoba, Winnipeg, Man.; Service de pneumologie, Hôpital Sainte-Justine, Montréal, ... Cited by 294 - Related articles - All 13 versions
- ►nih.gov [PDF] ER Sher, DY Leung, W Surs, JC Kam, G … - Journal of Clinical …, 1994 - pubmedcentral.nih.gov The current study examined whether alterations in glucocorti- coid receptor (GR) binding contribute
to poor response to glu- cocorticoid therapy in asthma. 29 asthma patients with forced expiratory
volume in 1s (FEV1) < 70% predicted were stud- ied. Patients were classified as steroid ... Cited by 284 - Related articles - BL Direct - All 6 versions
- ►oxfordjournals.org [PDF] JM Drazen, EK Silverman, TH Lee - British medical bulletin, 2000 - British Council Asthma is a complex clinical syndrome with multiple genetic and environmental factors contributing
to its phenotypic expression. This aetiological heterogeneity adds to the complexity when addressing
variation in the response to anti- asthma treatment. Currently, there are three main lines of ... Cited by 127 - Related articles - BL Direct - All 4 versions
MTS Chan, DYM Leung, SJ Szefler, JD Spahn - Journal of Allergy and Clinical …, 1998 - Elsevier In 1977, Turner-Warwick 3 described patterns of GC response among asthmatic subjects in a
few patients. On the basis of data obtained from serial peak flow measurements, she described
the “brittle” asthmatic subjects and the “irreversible” asthmatic subjects. The “brittle” ... Cited by 99 - Related articles - BL Direct - All 5 versions
PJ Barnes, IM Adcock - Qjm, 1995 - Oxford Univ Press Resistance to the anti-inflammatory effects of gluco- corticoids in asthma and other inflammatory
and immune diseases is uncommon, but presents a man- agement problem. Understanding
the mechanisms of steroid resistance provides new insights into the mechanism of steroid ... Cited by 89 - Related articles - BL Direct - All 3 versions
- ►bmj.com PS Thomas, DM Geddes, PJ Barnes - British Medical Journal, 1999 - thorax.bmj.com CASE 1 A 38 year old woman presented with difficulty in breathing for 17 years. She had had
asthma as a child until the age of seven. She had been symptom free until the age of 21 when
she was treated for breathlessness with an inhaled 2 agonist as required, but due to ... Cited by 69 - Related articles - BL Direct - All 7 versions
