- ►bloodjournal.org JL Spivak - Blood, 2002 - Am Soc Hematology Polycythemia vera is a clonal disorder arising in a multipotent hematopoietic progenitor cell that
causes the accumulation of morphologically normal red cells, white cells, platelets, and their
progenitors in the absence of a definable stimulus and to the exclusion of nonclonal ... Cited by 223 - Related articles - BL Direct - All 7 versions
SA Landaw - Seminars in hematology, 1976 - ncbi.nlm.nih.gov Virtually every aspect concerning the occurrence of acute leukemia in polycythemia vera is
controversial. However, a list of those factors believed to have importance in leukemogenesis
in this disease includes: maleness, ethnic origin, the presence of myeloid metaplasia ... Cited by 143 - Related articles - All 3 versions
- ►hematologylibrary.org JL Spivak, G Barosi, G Tognoni, T … - …, 2003 - asheducationbook. … In Section I, Dr. Jerry Spivak introduces current clinical controversies involving the CMPD, in
particular the diagnostic challenges. Two new molecular assays may prove useful in the diagnosis
and classification of CMPD. In 2000, the overexpression in PV granulocytes of the mRNA ... Cited by 94 - Related articles - All 7 versions
- ►hematologylibrary.org Y Najean, JD Rain - Blood, 1997 - bloodjournal.hematologylibrary.org Despite myelosuppression, polycythemic (PV) patients greater than 65 years of age have a high
risk of vascular complications, and the leukemic risk exceeds 15% after 12 years. Is the addition
of low-dose maintenance treatment with hydroxyurea (HU) after radiophosphorus ( 32 P) ... Cited by 65 - Related articles - BL Direct - All 5 versions
A CA - CA A Cancer Journal for Clinicians - interscience.wiley.com The analysis of 288 cases of polycythemia vera (PV) with a minimal follow-up of 10 years enabled
us to study the characteristics of acute leukemia as observed in 33 patients (11.4%). In 50% of
the patients (16 of 33), the malignant transformation is of the refractory anemia with ... Cited by 50 - Related articles - All 3 versions
HL Davis Jr, MN Prout, PJ McKenna, DR Cole … - CA A Cancer Journal … - interscience.wiley.com Acute leukemia occurred in two women after prolonged chemotherapy for metastatic carcinoma
of the breast. Palliative radiation therapy was given to both patients within 18 and 22
months, respectively, before the onset of acute leukemia, but the short interval between ... Cited by 50 - Related articles - All 2 versions
DS Rosenthal, WC Moloney - British journal of haematology, 1977 - ncbi.nlm.nih.gov In a series of 306 cases of myeloproliferative disorders followed over a period of 21 years, 18
cases of well-documented acute leukaemia were encountered. Leukaemias were either acute
myeloblastic or myelomonocytic and occurred from 6 months to 20 years after the initial ... Cited by 46 - Related articles
A Weinfeld, J Westin, B Ridell, B Swolin - Scandinavian journal of …, 1977 - ncbi.nlm.nih.gov A total of 120 patients with polycythaemia vera (PV) were observed between 1971-1976. 8 of
them developed acute leukaemia (AL). The clinical course, cytogenetic and morphologic findings
of these patients are described in detail. Alkylating agents were the main treatment for all ... Cited by 42 - Related articles
EM Greenspan, BG Tung - Jama, 1974 - Am Med Assoc Two patients with advanced stage III ovarian cancer had complete regressions after intensive
therapy with thiotepa and methotrexate. Both patients showed unusual sensitivity while on maintenance
doses of thiotepa. Marrow hypoplasia occurred for several years before gradual ... Cited by 38 - Related articles - All 2 versions
