ML Mendelsohn, BH Mayall, E Bogart, DH … - Science (New York, …, 1973 - ncbi.nlm.nih.gov The chromosomes of two human males were identified by fluorescent banding, restained, and
measured by scanning microscopy and computer analysis. The two variables, DNA content and
DNA-based centromeric index, provided almost complete discrimination of chromosome ... Cited by 153 - Related articles - All 3 versions
- ►nih.gov [PDF] T Hovi, JF Smyth, AC Allison, SC … - Clinical and Experimental …, 1976 - pubmedcentral.nih.gov SUMMARY Activity of adenosine deaminase (ADA), an enzyme known to bedeficient in some
patients with severe combined immunodeficiency, increased three-fold within a 24-hr exposure
of human peripheral blood lymphocytes to phytohaemagglutinin (PHA) in culture. This ... Cited by 124 - Related articles - All 2 versions
- ►umich.edu [PDF] IH Fox - Metabolism, 1981 - deepblue.lib.umich.edu Purine nucleotide degradation refers to a regulated series of reactions by which human purine
ribonucleotides and deoxyribonucleotides are degraded to uric acid in humans. Two major types
of disorders occur in this pathway. A block of degradation occurs with syndromes ... Cited by 95 - Related articles - View as HTML - All 2 versions
MA Becker, LJ Meyer, AW Wood, JE Seegmiller - Science, 1973 - sciencemag.org In hemolyzates from red cells of two brothers with purine overproduction and gout, activity of
phosphoribosylpyrophosphate synthetase is more than twofold greater than that measured in
normal or other gouty individuals. The increased enzyme activity, which is also ... Cited by 63 - Related articles - All 4 versions
HJ Becher, GW Löhr - Journal of Molecular Medicine, 1979 - Springer Zusammenfassung. Die Aktivit/it der Inosinsfiure De- hydrogenase (EC 1.2.1. [14]) wurde in normalen
und leukfimischen Leukozyten gemessen. Die Enzyme wurden partiell gereinigt und einige der
kinetischen Eigenschaften untersucht. Von den normalen Blutzel- len besal3en die ... Cited by 49 - Related articles - All 2 versions
AB Gutman, M Phd - Arthritis Care & Research - interscience.wiley.com Advances in management of acute gouty arthritis, tophaceous gout and uric acid nephrolithiasis
are briefly reviewed. With respect to pathogenesis, specific enzyme abnormalities have been
demonstrated in rare monogenic cases but the presumptive polygenic and multifactorial ... Cited by 46 - Related articles - All 2 versions
MA Becker, LJ Meyer, JE Seegmiller - The American Journal of Medicine, 1973 - Elsevier Two brothers with marked purine overproduction and clinical gout showed activity of the enzyme
phosphoribosylpyrophosphate (PP-ribose-P) synthetase in erythrocyte lysates 2.5 to 3.0-fold
greater than that found in normal subjects or in other patients with gout. Associated with ... Cited by 48 - Related articles - All 2 versions
- ►pnas.org [PDF] MA Becker, PJ Kostel, LJ Meyer, JE … - Proceedings of the …, 1973 - National Acad Sciences Page 1. Proc. Nat. Acad. Sci. USA Vol. 70, No. 10, pp. 2749-2752, October 1973 Human
Phosphoribosylpyrophosphate Synthetase: Increased Enzyme Specific Activity in a Family with
Gout and Excessive Purine Synthesis (structural mutation/genetic variation) ... Cited by 51 - Related articles - All 7 versions
- ►nih.gov [PDF] E Zoref, A De Vries, O Sperling - Journal of Clinical Investigation, 1975 - pubmedcentral.nih.gov ABSTRACT We have reported previously two sib- lings with gout and uric acid lithiasis associated
with excessive purine production. In the erythrocytes of these patients, phosphoribosylpyrophosphate
(PRPP) syn- thetase exhibited resistance to feedback-inhibition by normal cell ... Cited by 47 - Related articles - All 4 versions
CD Green, DW Martin - Proceedings of the National Academy of …, 1973 - National Acad Sciences CHRISTOPHER D. GREEN AND DAVID W. MARTIN,JR.* Departments of Medicine and
Biochemistry, School of Medicine, University of California, San Francisco, San Francisco,
Calif. 94143 Communicated by IS Edelman, August 13, 1973 ABSTRACT A clone of cells ... Cited by 43 - Related articles - All 7 versions
