YM Lee, DJ Kim - Current Treatment Options in Gastroenterology, 2001 - Springer Introduction Primary sclerosing cholangitis (PSC) is a chronic progressive liver disorder that
is characterized by ongoing inflammation, obliteration, and fibrosis of both intrahepatic and extrahepatic
bile ducts. Diffuse strictures with short intervening segments of normal or dilated bile ... Cited by 370 - Related articles - BL Direct - All 7 versions
EA Jones, NV Bergasa - Hepatology, 1999 - usagiedu.com PATHOGENESIS Although the pathophysiological changes responsible for mediating the pruritus
of cholestasis may be present in all cholestatic patients, there may be interindividual differences
that influence its perception. This concept is suggested by the lack of correlation between ... Cited by 206 - Related articles - BL Direct - All 9 versions
- ►upenn.edu [PDF] JA Talwalkar, KD Lindor - The Lancet, 2003 - Elsevier Primary biliary cirrhosis is a chronic cholestatic liver disease of adults. This disorder is characterised
histologically by chronic non-suppurative destruction of interlobular bile ducts leading to advanced
fibrosis, cirrhosis, and liver failure. The precise aetiopathogenesis of primary biliary ... Cited by 196 - Related articles - All 8 versions
WF Balistreri - The Journal of pediatrics, 1985 - Elsevier THE JOURNAL OF PEDIATRICS FEBRUARY 1985 Volume 106 Number 2 MEDICAL PROGRESS
Comment: The facts and ideas set forth in this paper address a spectrum of problems that have
baffled good clinicians foryears. Many of our readers will remember attempts to resolve ... Cited by 172 - Related articles - All 6 versions
- ►angrylapdog.com R Twycross, MW Greaves, H Handwerker, … - Qjm, 2003 - qjmed.oxfordjournals.org.p. … In origin, itch can be cutaneous ('pruritoceptive', eg dermatitis), neuropathic (eg multiple
sclerosis), neurogenic (eg cholestasis), mixed (eg uraemia) or psychogenic. Although itch of
cutaneous origin shares a common neural pathway with pain, the afferent C-fibres ... Cited by 147 - Related articles - BL Direct - All 6 versions
GL Guo, G Lambert, M Negishi, JM Ward, HB … - Journal of Biological …, 2003 - ASBMB The nuclear receptors, farnesoid X receptor (FXR) and pregnane X receptor (PXR), are important
in maintaining bile acid homeostasis. Deletion of both FXR and PXR in vivo by cross-breeding
B6;129-Fxr tm1Gonz (FXR-null) and B6;129-Pxr tm1Glaxo-Wellcome (PXR-null) mice ... Cited by 144 - Related articles - BL Direct - All 5 versions
- ►meduniwien.ac.at [PDF] NV Bergasa - Journal of hepatology, 2005 - Elsevier The absence of a clear rationale in studies of pruritus and the lack of techniques to study pruritus
in human beings, and specifically, in patients with cholestasis have contributed to the vacuum
of information on the pathophysiology and pathogenesis of the pruritus of cholestasis. ... Cited by 93 - Related articles - BL Direct - All 10 versions
M Trauner, M Wagner, P Fickert, G … - Journal of Clinical …, 2005 - journals.lww.com Supported by Grant No. P15502 from the Austrian Science Foundation (to MT), Grant No. 10266
from the Jubilee Funds of the Austrian National Bank (to MT), and a GEN-AU grant from the Austrian
Ministry for Science (to MT). ... Reprints: Michael Trauner, MD, Laboratory for ... Cited by 75 - Related articles - All 2 versions
A Podesta, P Lopez, R Terg, F Villamil, D Flores, R … - Digestive diseases and …, 1991 - Springer Pruritus can be a debilitating symptom in patients with chronic cholestasis. Based on previous
reports of its efficacy, we evaluated the impact of rifampin on the pruritus associated with primary
biIiary cirrhosis. Fourteen patients were included in a random- ized, crossover study. After ... Cited by 69 - Related articles - All 3 versions
C Müller, S Pongratz, J Pidlich, E Penner, A … - European journal of …, 1998 - journals.lww.com 866 European Journal of Gastroenterology & Hepatology 1998, Vol 10 No 10 which is assumed
to play a role in nociception [19], to the pathogenesis of cholestatic pruritus. To further study the
effect of ondansetron on the severity of pruritus in chronic liver disease we performed a ... Cited by 63 - Related articles - BL Direct - All 3 versions
