M Divoll, DJ Greenblatt, JS Harmatz, RI … - J Pharm Sci, 1981 - interscience.wiley.com Thirty-two male and female volunteers, 24-84 years of age, ingested single 30-mg
doses of temazepam, a 3-hydroxy-1,4-benzodi-azepine derivative used as a
hypnotic agent. Kinetics of total and unbound temazepam were determined ... Cited by 107 - Related articles - All 2 versions
I Tegeder, J Lotsch, G Geisslinger - Clinical pharmacokinetics, 1999 - ingentaconnect.com Abstract The liver is the major site of biotransformation for most opioids.
Thus, the disposition of these drugs may be affected in patients with liver
insufficiency. The major metabolic pathway for most opioids is oxidation. ... Cited by 98 - Related articles - BL Direct - All 3 versions
RA Branch - Hepatology, 1982 - interscience.wiley.com It is well recognized that liver disease may influence the disposition of many
drugs. Conversely, it has been suggested that knowledge of the disposition of a
model drug might provide an index of certain aspects of hepatic function. ... Cited by 87 - Related articles - All 2 versions
- ►nih.gov [PDF] DJ Greenblatt, RI Shader, M Divoll, JS … - British Journal of Clinical Pharmacology, 1981 - pubmedcentral.nih.gov 1 The onset and duration of action of benzodiazepines after single oral doses
depend largely on absorption rate and the rate and extent of distribution,
respectively. 2 The rate and extent of accumulation during multiple dosage ... Cited by 80 - Related articles - All 3 versions
G Bakti, HU Fisch, G Karlaganis, C Minder, J … - Hepatology, 1987 - interscience.wiley.com Mechanisms responsible for disproportional sedation resulting from triazolam
administration to patients with cirrhosis were investigated. Ordinary sedative
doses (0.25 mg) were given po to 8 cirrhotics and 18 controls. Plasma ... Cited by 70 - Related articles - All 3 versions
A Hoyumpa, S Schenker - Hepatology, 1991 - interscience.wiley.com It is also possible that your web browser is not configured or not able to
display style sheets. In this case, although the visual presentation will be
degraded, the site should continue to be functional. We recommend using the ... Cited by 63 - Related articles - All 3 versions
- ►nih.gov [PDF] AJ MacGilchrist, GG Birnie, A Cook, G Scobie … - British Medical Journal, 1986 - gut.bmj.com Page 1. doi:10.1136/gut.27.2.190 1986;27;190-195 Gut Watkinson and MJ Brodie
AJ MacGilchrist, GG Birnie, A Cook, G Scobie, T Murray, G ... Cited by 60 - Related articles - All 6 versions
AM Hoyumpa Jr, S Schenker - Annual Review of Medicine, 1982 - Annual Reviews The liver, by virtue of its extensive array of enzyme activities, plays a vital
role in drug metabolism. Moreover, its location in relation to the splanchnic
circulation makes it an effective barrier against the systemic distribution ... Cited by 53 - Related articles - All 3 versions
