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Scholar Results 1 - 10 of about 46 citing MITCHELL: Purinogenic immunodeficiency diseases: clinical features and molecular mechanisms. (0.08 sec) 

Severe allopurinol toxicity* 1:: Description and guidelines for prevention in patients with …


KR Hande, RM Noone, WJ Stone - The American journal of medicine, 1984 - Elsevier
A life-threatening toxicity syndrome consisting of an erythematous, desquamative
skin rash, fever, hepatitis, eosinophilia, and worsening renal function in 78
patients receiving allopurinol is described. In a majority of cases, the ...
Cited by 238 - Related articles - All 5 versions

Low-dose deoxycoformycin in lymphoid malignancy

- ascopubs.org [PDF] 
MR Grever, JM Leiby, EH Kraut, HE Wilson, JA … - Journal of Clinical Oncology, 1985 - jco.ascopubs.org
Deoxycoformycin (dCF), a potent inhibitor of adeno- sine deaminase (ADA), was
explored for its antineo- plastic potential in 28 patients with advanced
lymphoid malignancy. Both normal and malignant B lymphocytes have low ...
Cited by 113 - Related articles - All 5 versions

Inhibition of adenosine deaminase activity results in cytotoxicity to T lymphoblasts in vivo

- bloodjournal.org [PDF] 
BS Mitchell, CA Koller, R Heyn - Blood, 1980 - Am Soc Hematology
. Hematology; all rights reserved Copyright 2007 by The American Society of DC
20036. by the American Society of Hematology, 1900 M St, NW, Suite 200,
Washington Blood (print ISSN 0006-4971, online ISSN 1528-0020), is ...
Cited by 51 - Related articles - All 3 versions

Metabolic basis of arabinonucleoside selectivity for human leukemic T-and B-lymphoblasts

- aacrjournals.org [PDF] 
V Verhoef, A Fridland - Cancer Research, 1985 - AACR
Purine deoxyribonucleosides can selectively alter lymphocyte proliferation and
function. Inherited abnormalities in dAdo3 and dGuo metabolism have been
associated with selective depletion of lymphoid cells in humans. Adenosine ...
Cited by 46 - Related articles - All 3 versions

Phenotypic conversion of acute leukaemia from T-lymphoblastic to myeloblastic induced by …


SB Murphy, S Stass, D Kalwinsky, G Rivera - British journal of haematology, 1983 - ncbi.nlm.nih.gov
A 6-year-old boy with T-cell acute lymphoblastic leukaemia (ALL) in relapse was
treated with the adenosine deaminase inhibitor, 2'-deoxycoformycin (DCF).
Remarkably, his residual leukaemia underwent an abrupt phenotypic shift, ...
Cited by 45 - Related articles

CD4 cell decline with didanosine and tenofovir and failure of triple nucleoside/nucleotide …


TN Kakuda, PL Anderson, SL Becker - Aids, 2004 - journals.lww.com
The patient was a 41-year-old homosexual man, with a 13-year history of HIV,
complicated by neuropathy, gastroesophageal reflux disease and depression, who
was admitted to the hospital with abdominal pain. He described 5 days of ...
Cited by 35 - Related articles - All 2 versions

Adenosine deaminase deficiency with normal immune function. An acidic enzyme mutation.

- nih.gov [PDF] 
PE Daddona, BS Mitchell, HJ Meuwissen, BL … - Journal of Clinical Investigation, 1983 - pubmedcentral.nih.gov
A BS TRA CT In most instances, marked deficiency of the purine catabolic enzyme
adenosine deaminase results in lymphopenia and severe combined immu-
nodeficiency disease.Over a 2-yr period, we studied a white malechild with ...
Cited by 35 - Related articles - All 5 versions

Prolonged depletion of guanosine triphosphate induces death of insulin-secreting cells by …

- endojournals.org
G Li, VBG Segu, ME Rabaglia, RH Luo, A … - Endocrinology, 1998 - Endocrine Soc
Inhibitors of IMP dehydrogenase, such as mycophenolic acid (MPA) and mizoribine,
which deplete cellular GTP, are used clinically as immunosuppressive drugs. The
prolonged effect of such agents on insulin-secreting ß-cells (HIT-T15 and ...
Cited by 33 - Related articles - BL Direct - All 5 versions

Dose-dependent influence of didanosine on immune recovery in HIV-infected patients treated …

- infekt.ch [PDF] 
U Karrer, B Ledergerber, H Furrer, L Elzi, M … - Aids, 2005 - journals.lww.com
Background: Antiretroviral therapy (ART) containing tenofovir disoproxil
fumarate (TDF) and didanosine (ddI) has been associated with poor immune
recovery despite virologic success. This effect might be related to ddI ...
Cited by 27 - Related articles - BL Direct - All 10 versions

Compromised immunologic recovery in treatment-experienced patients with HIV infection …


E Negredo, A Bonjoch, R Paredes, J Puig, B … - Clinical Infectious Diseases, 2005 - UChicago Press
Featured in New York Times "Searching the Web for Flu Outbreaks" November 28,
2008 Using Internet Searches for Influenza Surveillance Philip M. Polgreen,
Yiling Chen, David M. Pennock, and Forrest D. Nelson One study, published ...
Cited by 23 - Related articles - BL Direct - All 4 versions


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