D Liao, RS Johnson - Cancer and Metastasis Reviews, 2007 - Springer Abstract Angiogenesis is an important mediator of tumor progression. As tumors expand, diffusion
distances from the existing vascular supply increases resulting in hypoxia. Sustained expansion
of a tumor mass requires new blood vessel formation to provide rapidly proliferating tumor ... Cited by 84 - Related articles - BL Direct - All 3 versions
- ►aacrjournals.org Y Rong, DE Post, RO Pieper, DL Durden, EG Van Meir, … - Cancer research, 2005 - AACR We have previously proposed that intravascular thrombosis and subsequent vasoocclusion contribute
to the development of pseudopalisading necrosis, a pathologic hallmark that distinguishes glioblastoma
(WHO grade 4) from lower grade astrocytomas. To better understand the potential ... Cited by 74 - Related articles - All 4 versions
SM Evans, KD Judy, I Dunphy, WT Jenkins, WT Hwang, … - Clinical cancer research, 2004 - AACR We investigated whether increasing levels of tissue hypoxia, measured by the binding of EF5
[2-(2-nitro-1-H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl) acetamide] or by Eppendorf needle
electrodes, were associated with tumor aggressiveness in patients with previously ... Cited by 56 - Related articles - All 5 versions
Y Rong, DL Durden, EG Van Meir, DJ … - Journal of Neuropathology …, 2006 - journals.lww.com Abstract Glioblastoma (GBM) is a highly malignant, rapidly progressive astrocytoma that is distinguished
pathologically from lower grade tumors by necrosis and microvascular hyperplasia. Necrotic
foci are typically surrounded by Bpseudopalisading^ cellsVa configuration that is ... Cited by 53 - Related articles - BL Direct - All 3 versions
- ►snmjournals.org LM Cher, C Murone, N Lawrentschuk, S … - Journal of Nuclear …, 2006 - Soc Nuclear Med PET offers a noninvasive means to assess neoplasms, in view of its sensitivity and accuracy
in staging tumors and potentially in monitoring treatment response. The aim of this study was
to evaluate newly diagnosed primary brain tumors for the presence of hypoxia, as ... Cited by 45 - Related articles - BL Direct - All 3 versions
- ►aacrjournals.org C Charalambous, LB Pen, YS Su, J Milan, TC Chen, … - Cancer research, 2005 - AACR Interleukin-8 (IL-8) is a chemokine involved in angiogenesis, a process vital to tumor growth.
Previously, we showed that endothelial cells derived from human tumor tissue have different
functional and phenotypic properties compared with normal endothelial cells. This study ... Cited by 29 - Related articles - BL Direct - All 7 versions
V Jendrossek, C Belka, M Bamberg - eid, 2003 - Informa Pharma Science During the last few decades, the discovery of novel targets for therapeutic intervention led to
the development of chemotherapeutic agents that specifically interfere with altered cellular functions
of tumour cells. Genetic alterations in glioblastoma affect cell proliferation and cell cycle ... Cited by 26 - Related articles - BL Direct - All 4 versions
RL Jensen - Neurosurgical Focus, 2006 - phx1.medscape.com In this article, the author provides a brief description of the role of hypoxia in the tumorigenesis
of gliomas and suggests potential ways of exploiting this role to design treatment modalities.
Tumor hypoxia predicts the likelihood of metastases, tumor recurrence, resistance to ... Cited by 20 - Related articles - All 7 versions
- ►aacrjournals.org Y Rong, F Hu, RP Huang, N Mackman, JM Horowitz, … - Cancer research, 2006 - AACR Glioblastoma multiforme is the most common form of malignant glioma and is characterized by
widespread invasiveness, tumor necrosis, and angiogenesis (1). Microscopic intravascular thrombosis
can be identified in >90% of glioblastoma multiforme specimens and vaso-occlusive ... Cited by 21 - Related articles - BL Direct - All 4 versions
DH Nam, K Park, YL Suh, JH Kim - Oncology reports, 2004 - ncbi.nlm.nih.gov Brain specific angiogenesis inhibitor (BAI)-1 is a novel p53-inducible anti-angiogenic
molecule. We examined the expression of BAI-1 in glial tumors and its association with patient
survival. The expression of BAI-1 was evaluated in 20 brain tumors (meningiomas, ... Cited by 17 - Related articles - BL Direct - All 4 versions
