S McFarlane, JV Glenn, AM Lichanska, DAC … - British Journal of Ophthalmology, 2005 - bjo.bmj.com Aims: Advanced glycation endproducts (AGEs) accumulate with ageing and may have
a significant impact on age related dysfunction of the retinal pigment
epithelium (RPE). Many of the cellular effects of AGEs in other cell types ... Cited by 16 - Related articles - All 8 versions
- ►nih.gov J Tian, K Ishibashi, K Ishibashi, K Reiser, R … - Proceedings of the National Academy of Sciences, 2005 - National Acad Sciences Advanced glycation endproduct (AGE) formation is a trigger for the onset of
age-related disease. To evaluate AGE-induced change in the ocular fundus,
5-mo-old C57BL/6 mice were given low-dose d-galactose (d-gal) for 8 wk and ... Cited by 19 - Related articles - BL Direct - All 8 versions
- ►iovs.org W Ma, SE Lee, J Guo, W Qu, BI Hudson, AM … - Investigative ophthalmology & visual science, 2007 - ARVO METHODS. ARPE-19 cells were used for all experiments. The cells were transfected
with constructs encoding a signal transduction mutant of human RAGE to assess
the RAGE-dependence of intracellular signaling. VEGF secretion and gene ... Cited by 23 - Related articles - BL Direct - All 4 versions
Y Yamada, K Ishibashi, K Ishibashi, IA Bhutto, … - Experimental eye research, 2006 - Elsevier Basal deposits within Bruch's membrane are associated with aging and age-related
macular degeneration (AMD) although the factors causing their formation are
incompletely understood. Advanced glycation endproducts (AGEs) accumulate ... Cited by 26 - Related articles - All 3 versions
- ►fasebj.org JV Glenn, JR Beattie, L Barrett, N Frizzell, … - The FASEB Journal, 2007 - FASEB The modification of proteins by nonenzymatic glycation leading to accumulation
of advanced glycation end products (AGEs) is a well-established phenomenon of
aging. In the eyes of elderly patients, these adducts have been observed in ... Cited by 9 - Related articles - BL Direct - All 5 versions
P Canning, JV Glenn, DK Hsu, FT Liu, TA … - Exp Diabetes Res, 2007 - hindawi.com Breakdown of the inner blood-retinal barrier (iBRB) occurs early in diabetes and
is central to the development of sight-threatening diabetic macular edema (DME)
as retinopathy progresses. In the current study, we examined how advanced ... Cited by 11 - Related articles - View as HTML - All 15 versions
Y Cheng, MH Gao - Cellular & molecular immunology, 2005 - cmi.ustc.edu.cn Vascular proliferation is one of the major causes for morbidityand mortality in
diabetes. However, the cellular and molecular mechanisms that link hyperglycemia
to this complication remain unclear. In present study, we demonstrated by ... Cited by 2 - Related articles - View as HTML - All 2 versions
L Rodríguez-Mañas, C Sánchez-Rodríguez, S … - British journal of pharmacology, 2006 - pubmedcentral.nih.gov Diabetes mellitus is prevalent in the elderly population. It is also a disease
causing tissue damage through several different mechanisms. Some of these
mechanisms are also activated by ageing and this overlap raises questions ... Cited by 4 - Related articles - BL Direct - All 4 versions
- ►nih.gov P Alizadeh, Z Smit-McBride, SL Oltjen, LM … - Experimental eye research, 2006 - Elsevier Cystatin C is the major inhibitor of the cysteine cathepsins. Polymorphisms in
the cystatin C gene have recently been associated with the risk of developing
Age-related Macular Degeneration (AMD). Oxidative stress is also thought to ... Cited by 4 - Related articles - All 6 versions
JV Glenn, H Mahaffy, K Wu, G Smith, R Nagai … - Investigative Ophthalmology & Visual Science, 2009 - ARVO PURPOSE. Advanced glycation end products (AGEs) accumulate during aging and have
been observed in postmortem eyes within the retinal pigment epithelium (RPE),
Bruch's membrane, and subcellular deposits (drusen). AGEs have been ... Cited by 4 - Related articles - All 2 versions
