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Scholar Results 1 - 10 of about 101 related to Nakahara: A randomised, placebo controlled clinical trial of the aldose reductase inhibitor.... (0.11 sec) 

A randomised, placebo controlled clinical trial of the aldose reductase inhibitor CT-112 as …

- nih.gov - Free from Publisher
M Nakahara, K Miyata, S Otani, T Miyai, R … - British Journal of Ophthalmology, 2005 - bjo.bmj.com
Methods: This was a prospective, randomised, double masked placebo controlled
study. 34 eyes of 34 diabetic patients were randomly assigned treatment with
0.25% eye drops of CT-112 (n = 22) or a placebo (n = 12) four times a day ...
Cited by 10 - Related articles - All 10 versions

[CITATION] Development of complications in diabetic dogs and galactosemic dogs: effect of aldose …


TS Kern, RL Engerman - Proceedings of a workshop on aldose reductase …, 1991
Cited by 3 - Related articles

Unusual Binding Mode of the 2 S 4 R Stereoisomer of the Potent Aldose Reductase Cyclic Imide …


HT Zhao, I Hazemann, A Mitschler, V Carbone, … - Journal of Medicinal Chemistry, 2008 - pubs.acs.org
In this study we report the structure of ALR2 holoenzyme complexed with the 2S4R
stereoisomer of Fidarestat (Scheme 2) determined with X-ray diffraction data
collected at a temperature of 15 K and refined at 0.78 Å resolution. The ...
Cited by 3 - Related articles - All 3 versions

Association between sorbitol dehydrogenase gene polymorphisms and type 2 diabetic …


JP Szaflik, I Majsterek, M Kowalski, P Rusin, A … - Experimental Eye Research, 2008 - Elsevier
Diabetic retinopathy (DR) may affect 98% of diabetic patients, but its aetiology
is poorly understood. Besides glycaemic exposure, genetic factors likely
contribute to the onset of DR. The polyol pathway, including aldose ...
Cited by 3 - Related articles - All 5 versions

Novel Aldose Reductase Inhibitors Derived from 6-(((Diphenylmethylene) amino oxy …


D Rakowitz, G Piccolruaz, C Pirker, B … - Archiv der Pharmazie, 2007 - interscience.wiley.com
Starting from the recently identified aldose reductase inhibitor
6-[[(diphenylmethylene)amino]oxy]hexanoic acid 1, the following systematic
structural modifications were performed: (a) formal substitution of the ...
Cited by 4 - Related articles - BL Direct - All 4 versions

Renal and microvascular effects of an aldose reductase inhibitor in experimental diabetes. …


JP Kassab, R Guillot, J Andre, N Claperon, G … - Biochemical pharmacology, 1994 - ncbi.nlm.nih.gov
Aldose reductase inhibitors, and particularly sorbinil, have been reported to
prevent glomerular basement membrane thickening (GBMT) and albuminuria
development in diabetic rats, but contradictory observations have been ...
Cited by 7 - Related articles - BL Direct - All 2 versions

[CITATION] The Quantum Theory of Atoms in Molecules: From Solid State to DNA and Drug Design, …


L Leherte, B Guillot, DP Vercauteren, V …, 2006 - Matta
Cited by 2 - Related articles

Fidarestat. Sanwa Kagaku/NC Curex/Sankyo.


N Giannoukakis - Current opinion in investigational drugs (London, …, 2003 - ncbi.nlm.nih.gov
1: Curr Opin Investig Drugs. 2003 Oct;4(10):1233-9. Fidarestat. Sanwa
Kagaku/NC Curex/Sankyo. Giannoukakis N. University of Pittsburgh ...
Cited by 3 - Related articles - BL Direct - All 3 versions

Epalrestat prevents the decrease in gastric mucosal blood flow and protects the gastric …


H Suzuki, T Shimosegawa, S Ohara, T Toyota - Journal of gastroenterology, 1999 - Springer
Because chronic hyperglycemia is associated with systemic micro-circulatory
disturbances, 1 some changes may also occur in gastric mucosal blood flow (GMBF)
in diabetic patients. However, whether diabetic patients are more ...
Cited by 11 - Related articles - BL Direct - All 5 versions

Corneal epithelial barrier function in diabetic patients


M Gekka, K Miyata, Y Nagai, S Nemoto, T … - Cornea, 2004 - journals.lww.com
Purpose: To evaluate the corneal epithelial barrier function in diabetic
patients. Methods: In 29 eyes of 29 diabetic patients and 55 eyes of 55
nondiabetic controls, corneal epithelial permeabil- ity to fluorescein was ...
Cited by 17 - Related articles - BL Direct - All 3 versions


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