- ►nih.gov - Free from Publisher FB Kalapesi, MT Coroneo, MA Hill - British Journal of Ophthalmology, 2005 - bjo.bmj.com Background/aim: Alpha-2α adrenergic receptor (α 2 -AR) agonists are thought to
be neuroprotective, preventing retinal ganglion cell death independent of
pressure reduction. Previous studies have identified α 2 -ARs in rat ... Cited by 12 - Related articles - All 8 versions
E WOLDEMUSSIE, M WIJONO, D POW - Visual Neuroscience, 2007 - Cambridge Univ Press Abstract Alpha 2 adrenergic agonists are used for controlling intraocular
pressureIOP! in the treatment of glaucoma. They have also been shown to be
neuroprotective to retinal cells in a variety of injury models. Despite ... Cited by 3 - Related articles - BL Direct - All 2 versions
- ►iovs.org CJ Dong, Y Guo, L Wheeler, WA Hare - Investigative ophthalmology & visual science, 2007 - ARVO PURPOSE. Compelling evidence suggests that 2 agonists, such as brimonidine,
protect retinal ganglion cells (RGCs) from injury in a wide range of animal
models. However, the mechanism of action for this protection and the ... Cited by 3 - Related articles - BL Direct - All 3 versions
- ►iovs.org DC Baptiste, ATE Hartwick, CAB Jollimore, … - Investigative ophthalmology & visual science, 2002 - ARVO METHODS. Neuronal survival was measured in mixed retinal cell cultures treated
for 24 hours with media containing 100 µM glutamate, with or without the
addition of each of the drugs (1–1000 µM). Effects of glutamate on glia ... Cited by 27 - Related articles - BL Direct - All 6 versions
- ►iovs.org [PDF] JR Berlie, LJ Iversen, HS Blaxall, ME Cooley … - Investigative ophthalmology & visual science, 1995 - ARVO Purpose. To identify and characterize the alpha-2 adrenergic receptor subtypes
present in the bovine neurosensory retina. Methods. Radioligand saturation and
inhibition binding assays were performed with the antago- nist radioligands ... Cited by 16 - Related articles - BL Direct - All 3 versions
FAKM Ahmed, K Hegazy, P Chaudhary, SC … - Brain research, 2001 - Elsevier Brimonidine, a selective α 2 -adrenoceptor agonist, has recently been shown to
be neuroprotective as it significantly improves survival of retinal ganglion
cells (RGCs) after calibrated optic nerve injury in rats. In the present ... Cited by 28 - Related articles - All 4 versions
- ►aspetjournals.org JE Donello, EU Padillo, ML Webster, LA … - Journal of Pharmacology and Experimental …, 2001 - ASPET Recent studies have suggested that 2 -adrenergic agonists prevent neuronal cell
death in a number of animal models, although the mechanism of 2 -neuroprotection
remains unclear. In a retinal ischemia model, the 2 -specific agonist ... Cited by 81 - Related articles - BL Direct - All 3 versions
- ►iovs.org MP Lafuente, MP Villegas-Perez, P Sobrado- … - Investigative ophthalmology & visual science, 2001 - ARVO METHODS. RGCs were labeled with a Fluorogold (FG) tracer applied to both
superior colliculi. Seven days later, the left ophthalmic vessels were ligated
for 60 or 90 minutes. In one group, a single dose of saline or one 2 -SA ... Cited by 46 - Related articles - BL Direct - All 4 versions
J KUSARI, SX Zhou, E Padillo, KG Clarke, DW … - Investigative Ophthalmology & Visual Science, 2009 - ARVO Page 1. 1 Inhibition of Vitreoretinal VEGF Elevation and Blood-Retinal Barrier
Breakdown in Streptozotocin-Induced Diabetic Rats by Brimonidine ... Related articles - All 2 versions
