- ►nih.gov MA Majid, VA Smith, FJ Matthews, AC Newby, … - British Journal of Ophthalmology, 2006 - bjo.bmj.com Background: Sorsby's fundus dystrophy (SFD) is caused by mutations in tissue
inhibitor of metalloproteinase (TIMP)-3 and, with the exception of early onset,
is similar to age-related macular degeneration. The pathological features ... Cited by 2 - Related articles - BL Direct - All 7 versions
VA Smith, FJ Matthews, MA Majid, SD Cook - BBA-Molecular Basis of Disease, 2006 - Elsevier Keratoconus is an ocular condition that causes corneal thinning, cone formation
and scarring. In view of a hypothesis that activated MMP-2 may initiate or
facilitate disease progression, the MMP-2/TIMP systems of stromal cells ... Cited by 5 - Related articles - All 4 versions
MA Majid, VA Smith, DL Easty, AH Baker, AC … - FEBS letters, 2002 - Elsevier C-terminal domain tissue inhibitor of metalloproteinases-3 (TIMP-3) mutations
cause the rare hereditary blindness Sorsby's fundus dystrophy (SFD), which
involves loss of retinal pigment epithelial (RPE) cells. Since wild-type ... Cited by 15 - Related articles - All 6 versions
- ►bmj.com MA Majid, VA Smith, DL Easty, AH Baker, AC … - British Medical Journal, 2002 - bjo.bmj.com Background: Sorsby's fundus dystrophy (SFD) and age related macular degeneration
(ARMD) are retinal diseases associated with a high level of accumulation of
mutant and wild type TIMP-3, respectively, in Bruch's membrane. The ... Cited by 21 - Related articles - BL Direct - All 8 versions
- ►iovs.org NH Chong, RA Alexander, T Gin, AC Bird, PJ … - Investigative ophthalmology & visual science, 2000 - ARVO METHODS. The eyes of an SFD donor with a confirmed TIMP-3 mutation were examined
using histologic techniques demonstrating connective tissue, calcium, and lipid.
Immunohistochemical analyses were performed using antibodies against ... Cited by 34 - Related articles - BL Direct - All 4 versions
[CITATION] TIMP-3 accumulation in Bruch's membrane and drusen in eyes from normal and age-related …
M Kamei, SS Apte, ME Rayborn, H Lewis, JG … - Degenerative Retinal Diseases, 1997 Cited by 7 - Related articles
- ►oxfordjournals.org KP Langton, N McKie, BM Smith, NJ Brown, … - Human Molecular Genetics, 2005 - Oxford Univ Press Sorsby's fundus dystrophy (SFD) is an autosomal dominant degenerative disease of
the retina, caused by mutations in exon 5 of the gene for tissue inhibitor of
metalloproteinases-3 (TIMP-3). The mechanism by which these mutations give ... Cited by 7 - Related articles - BL Direct - All 5 versions
[CITATION] Perspectives for TNF-alpha-targeting therapies http://arthritis-research. com/content/4/S3/ …
MA Majid, VA Smith, AC Newby, AD Dick - British Journal of Ophthalmology, 2007 - bjo.bmj.com Methods: COS-7 cells were transfected with plasmids containing wild type, Ser
181, Gly-167, Ser-156, and Tyr-168 TIMP-3 cDNA. The cells and their matrices
were subsequently harvested and homogenised. After measuring the bound wild ... Related articles - BL Direct - All 5 versions
CE Arris, DJ Bevitt, J Mohamed, Z Li, KP … - BBA-Molecular Basis of Disease, 2003 - Elsevier Gingival fibroblast cell lines were derived from Sorsby's fundus dystrophy (SFD)
patients carrying the S181C TIMP3 and the E139X TIMP3 mutations. These cell
lines were grown in culture to study expression of the wild-type and mutant ... Cited by 6 - Related articles - All 6 versions
