- ►nih.gov DM Paskowitz, MM LaVail, JL Duncan - British Journal of Ophthalmology, 2006 - bjo.bmj.com Light deprivation has long been considered a potential treatment for patients
with inherited retinal degenerative diseases, but no therapeutic benefit has
been demonstrated to date. In the few clinical studies that have addressed ... Cited by 17 - Related articles - BL Direct - All 7 versions
C Jozwick, K Valter, J Stone - Experimental eye research, 2006 - Elsevier The present experiments were undertaken to test recovery of function in the
retina of the rhodopsin-mutant P23H-3 rat, in response to the management of
ambient light. Observations were made in transgenic P23H-3 and ... Cited by 8 - Related articles - All 4 versions
- ►iovs.org DA White, WW Hauswirth, S Kaushal, AS … - Investigative ophthalmology & visual science, 2007 - ARVO METHODS. Mice were bred to express the hT17M rhodopsin transgene in a line that
was hemizygous null for wild-type mouse rhodopsin (mrho +/– ), and the eyes of
transgenic mice and nontransgenic littermates were exposed for 2.5 minutes ... Cited by 8 - Related articles - BL Direct - All 4 versions
N Walsh, D van Driel, D Lee, J Stone - Brain research, 2004 - Elsevier The P23H transgenic rat was engineered to mimic a human form of retinal
degeneration caused by a mutation in rhodopsin. We have tested whether the P23H
transgene influences the vulnerability of photoreceptors to modest ... Cited by 17 - Related articles - All 4 versions
- ►nih.gov AV Cideciyan, SG Jacobson, TS Aleman, D Gu … - Proceedings of the National Academy of Sciences, 2005 - National Acad Sciences Genetic and environmental factors modify the severity of human
neurodegenerations. Retinal degenerations caused by rhodopsin gene mutations
show severity differences within and between families and even within ... Cited by 49 - Related articles - All 11 versions
- ►iovs.org V Chrysostomou, J Stone, S Stowe, NL Barnett … - Investigative Ophthalmology & Visual Science, 2008 - ARVO METHODS. P23H-3 rats were raised in scotopic cyclic (12 hours of 5 lux, 12 hours
of dark) ambient light. At postnatal day 90 to 130, some were transferred to
photopic conditions (12 hours of 300 lux, 12 hours of dark) for 1 week and ... Cited by 6 - Related articles - BL Direct - All 3 versions
J Stone, K Mervin, N Walsh, K Valter, JM … - Macular Degeneration, 2005 - books.google.com Chapter 9 Photoreceptor Stability,• and Degeneration in Mammalian Retina:
Lessons from the Edge Jonathan Stone, Kyle Mervin, Natalie Walsh, Krisztina
Valter, Jan M. Provis, Philip L. Penfold Contents 9.1 Introduction 149 9.2 ... Cited by 10 - Related articles
[CITATION] Protection of the dystrophic retina from susceptibility to light stress
V Chrysostomou, J Stone, K Valter - Investigative Ophthalmology & Visual Science, 2009 - ARVO RESULTS. In the P23H-3 retina, cone density followed a developmental pattern,
increasing from P10 until P20, declining during early adult life (to P150), then
steadying at levels found in the SD retina until P540. Cone OSs elongated ... Cited by 3 - Related articles - All 3 versions
