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Scholar Results 1 - 10 of about 55 related to Brea-Fernández: Novel splice donor site mutation in MERTK gene associated with retinitis pigmentosa. (0.13 sec) 

Novel splice donor site mutation in MERTK gene associated with retinitis pigmentosa


AJ Brea-Fernández, E Pomares, MJ Brión, G … - British Medical Journal, 2008 - bjo.bmj.com
Background/aim: Mutations in MERTK, a member of the MER/AXL/TYRO3 receptor
kinase family, have been associated with disruption of the Retinal Pigment
Epithelium (RPE) phagocytosis pathway and settling of autosomal recessive ...
Cited by 1 - Related articles - All 3 versions

JAK/STAT and PI3K/AKT pathways form a mutual transactivation loop and afford resistance …


CP Biochem - Cell Physiol Biochem, 2008 - content.karger.com
Cardiac tissues contain cells susceptible to and cells resistant to apoptosis,
and this difference is important for normal morphogenesis during development and
for abnormal loss of cells during pathogenesis such as myocardial ...
Cited by 5 - Related articles - BL Direct - All 4 versions

Autophosphorylation docking site Tyr-867 in Mer receptor tyrosine kinase allows for …

- jbc.org
N Tibrewal, Y Wu, V D'mello, R Akakura, TC … - Journal of Biological Chemistry, 2008 - ASBMB
Efficient clearance of apoptotic cells is essential for tissue homeostasis,
allowing for cellular turnover without inflammatory consequences. The Mer (Nyk
and c-Eyk) receptor tyrosine kinase (Mertk) is involved in two aspects of ...
Cited by 10 - Related articles - All 4 versions

The Mer receptor tyrosine kinase is required for the loss of B cell tolerance in the chronic …

- jimmunol.org
WH Shao, RA Eisenberg, PL Cohen - The Journal of Immunology, 2008 - Am Assoc Immnol
The Mer receptor tyrosine kinase mediates apoptotic cell phagocytosis and
modulates macrophage cytokine production. Mer –/– mice have defective
clearance of apoptotic debris and develop a systemic lupus ...
Cited by 2 - Related articles - All 3 versions

MerTK regulates thymic selection of autoreactive T cells

- j-talk.com
MA Wallet, RR Flores, Y Wang, Z Yi, CJ … - Proceedings of the National Academy of Sciences, 2009 - National Acad Sciences
T cell-mediated autoimmune diseases such as type 1 diabetes (T1D) are believed
to be the result in part of inefficient negative selection of self-specific
thymocytes. However, the events regulating thymic negative selection are ...
Cited by 1 - Related articles - All 9 versions

A novel role for c-Src and STAT3 in apoptotic cell-mediated MerTK-dependent …

- hematologylibrary.org
Z Yi, L Li, GK Matsushima, HS Earp, B Wang, … - Blood, 2009 - bloodjournal.hematologylibrary.org
Dendritic cells (DCs) play an instrumental role in regulating tolerance to
self-antigens and preventing autoimmunity. One mechanism by which "tolerogenic"
DCs are established is through the inhibitory effects of apoptotic cells ...
Related articles - All 2 versions

LIF-and IL-6-induced acetylation of STAT3 at Lys-685 through PI3K/Akt activation


N Ohbayashi, O Ikeda, N Taira, Y Yamamoto, … - Biological & pharmaceutical bulletin, 2007 - J-STAGE
Signal transducer and activator of transcription 3 (STAT3) is a member of the
STAT protein family, and is mainly acti- vated by the interleukin (IL)-6 family
of cytokines, interfer- ons, epidermal growth factor and leptin. 1,2) ...
Cited by 10 - Related articles - BL Direct - All 4 versions

STAT3-mediated constitutive expression of SOCS3 in an undifferentiated rat trophoblast-like …


A Isobe, T Takeda, M Sakata, T Yamamoto, R … - Placenta, 2006 - Elsevier
In the trophoblast, constitutive expression of SOCS3 is important for the
negative regulation of trophoblast giant cell differentiation. In this study, we
analyzed the signaling pathway regulating the constitutive SOCS3 expression ...
Cited by 11 - Related articles - All 8 versions

IL-6 signaling via the STAT3/SOCS3 pathway: functional analysis of the conserved STAT3 …

- nih.gov
L Zhang, DB Badgwell, JJ Bevers, K … - Molecular and cellular biochemistry, 2006 - Springer
Page 1. Molecular and Cellular Biochemistry 288: 179–189, 2006. DOI: 10.1007/s11010-
006-9137-3 c g Springer 2006 IL-6 signaling via the STAT3/SOCS3 pathway: ...
Cited by 12 - Related articles - BL Direct - All 5 versions

The Lyn tyrosine kinase differentially regulates dendritic cell generation and maturation

- jimmunol.org
CL Chu, CA Lowell - The Journal of Immunology, 2005 - Am Assoc Immnol
The Src family kinase Lyn plays both stimulatory and inhibitory roles in
hemopoietic cells. In this report we provide evidence that Lyn is involved in
dendritic cell (DC) generation and maturation. Loss of Lyn promoted DC ...
Cited by 14 - Related articles - BL Direct - All 4 versions


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