- ►nih.gov [PDF] - Free from Publisher NN Osborne, JPM Wood, G Chidlow, JH Bae, … - British Journal of Ophthalmology, 1999 - bjo.bmj.com Glaucomatous optic neuropathy is a chronic process which progresses over many
years. Data derived from clinical observations and from animal experiments
suggest that the axons of the optic nerve and the retinal ganglion cell ... Cited by 65 - Related articles - BL Direct - All 8 versions
NN Osborne, L DeSantis, JH Bae, M Ugarte, … - Experimental eye research, 1999 - Elsevier The present results show that topically applied Betoptic®(0.5% betaxolol) to
the rabbit or rat eye reaches the retina and can counteract the detrimental
effects caused by ischaemia/reperfusion or N -methyl- -aspartate ... Cited by 89 - Related articles - BL Direct - All 6 versions
CE CROSSON, JA WILLIS, DE POTTER - Journal of Ocular Pharmacology and Therapeutics, 1990 - liebertonline.com Page 1. JOURNAL OF OCULAR PHARMACOLOGY Volume 6, Number 4. 1990 Mary Ann Liebert,
Inc., Publishers Effect of the Calcium Antagonist, Nifedipine, ... Cited by 42 - Related articles - All 2 versions
NN Osborne, G Chidlow, MS Nash, JPM … - Current Opinion in Ophthalmology, 1999 - journals.lww.com Visual field loss in glaucoma is due to death of retinal ganglion cells.
Reducing or slowing down the loss of ganglion cells in glaucoma, a concept known
as neuroprotection, would appear to be the only way forward. This does not ... Cited by 43 - Related articles - BL Direct - All 2 versions
R Ritch - Current opinion in ophthalmology, 2000 - journals.lww.com Many categories of both natural and synthetic compounds have been reported to
have neuroprotective activity. These include not only antioxidants,
N-methyl-D-aspartate receptor antagonists, inhibitors of glutamate release, ... Cited by 30 - Related articles - BL Direct - All 4 versions
J Melena, JPM Wood, N N. Osborne - European journal of pharmacology, 1999 - Elsevier The effect of betaxolol on the specific binding of [ 3 H]diltiazem and [ 3
H]nitrendipine to rat cortical membranes was examined. Betaxolol inhibited
specific [ 3 H]diltiazem and [ 3 H]nitrendipine binding with IC 50 values ... Cited by 38 - Related articles - All 5 versions
NN Osborne, G Chidlow, JPM Wood, KG … - Current Eye Research, 2001 - informahealthcare.com Loss of vision leading to blindness is commonly due to pho- toreceptor or
ganglion cell malfunction. No evidence exists to suggest that a lesion
associated with other retinal cell- types (Müller cells, horizontal cells, ... Cited by 23 - Related articles - BL Direct - All 5 versions
- ►nih.gov [PDF] - Free from Publisher NN OSBORNE, J MELENA, G CHIDLOW, … - British Journal of Ophthalmology, 2001 - bjo.bmj.com Raised IOP is not the sole factor responsible for glaucomatous retinal damage
but an important one of a number that have been implicated (Fig 1).12-17 Only
10% of patients with increased IOP (⩾22 mm Hg) have glaucoma and between ... Cited by 58 - Related articles - BL Direct - All 14 versions
NN Osborne, M Ugarte, M Chao, G Chidlow, … - Survey of ophthalmology, 1999 - Elsevier Management of glaucoma is directed at the control of intraocular pressure (IOP),
yet it is recognized now that increased IOP is just an important risk factor in
glaucoma. Therapy that prevents the death of ganglion cells is the main ... Cited by 211 - Related articles - BL Direct - All 10 versions
HM Chao, G Chidlow, J Melena, JPM Wood, … - Brain research, 2000 - Elsevier There are a variety of possible ways in which neuroprotection can be induced
through activation of α 2 -adrenoceptors. Hypoxia/ischaemia is considered to
result in the excessive release of neurotransmitters from affected cells, ... Cited by 29 - Related articles - All 4 versions
