LJ Raffel, DC Robbins, JM Norris, E Boerwinkle, RA … - Diabetes Care, 1996 - Am Diabetes Assoc OBJECTIVE: To develop a resource, consisting of comprehensive data and lymphoblastoid cell
lines, of well-characterized NIDDM families that will be available to the scientific community for
genetic studies of NIDDM. RESEARCH DESIGN AND METHODS: Non-Hispanic white, ... Cited by 50 - Related articles - All 5 versions
KC Chiu, JE McCarthy - Metabolism: clinical and experimental, 1997 - ncbi.nlm.nih.gov Plasma angiotensin I-converting enzyme (ACE) levels are genetically predetermined and are
correlated with a deletion (D) insertion (I) polymorphism at the ACE gene locus. A subset of diabetic
patients are noted to have elevated ACE levels. Treatment with ACE inhibitors has been ... Cited by 44 - Related articles - BL Direct - All 5 versions
H Nishigori, S Yamada, T Kohama, T Utsugi, H … - Journal of Human …, 1998 - Springer Abstract Maturity-onset diabetes of the young (MODY3), a monogenic subtype of
non-insulin-dependent diabetes mellitus (NIDDM) with an early age of onset, is character- ized
by a primary defect in insulin secretion. Recently, it has been shown that mutations of the ... Cited by 19 - Related articles - BL Direct - All 4 versions
- ►endojournals.org SC Elbein, SJ Hasstedt, K Wegner, SE Kahn - Journal of Clinical …, 1999 - Endocrine Soc Both defective insulin secretion and insulin resistance have been reported in relatives of type
2 diabetic subjects. We tested 120 members of 26 families with a type 2 diabetic sibling pair with
a tolbutamide-modified, frequently sampled iv glucose tolerance test to determine the ... Cited by 106 - Related articles - BL Direct - All 5 versions
- ►nih.gov [PDF] MG Ehm, MC Karnoub, H Sakul, K Gottschalk, DC … - The American Journal of …, 2000 - Elsevier Type 2 diabetes is a serious, genetically influenced disease for which no fully effective treatments
are available. Identification of biochemical or regulatory pathways involved in the disease syndrome
could lead to innovative therapeutic interventions. One way to identify such pathways is ... Cited by 115 - Related articles - BL Direct - All 5 versions
N Babaya, H Ikegami, Y Kawaguchi, T Fujisawa, Y … - Acta Diabetologica, 1998 - Springer Abstract Recently, hepatocyte nuclear factor-1α(HNF-1α, which is encoded by the TCF1
gene) mutations were re- ported in a subset of patients with maturity onset diabetes of the young
(MODY3). We studied the contribution of TCF1 to genetic susceptibility to common non- ... Cited by 11 - Related articles - BL Direct - All 3 versions
- ►endojournals.org N Rasouli, T Hale, SE Kahn, HJ Spencer, SC … - Journal of Clinical …, 2005 - Endocrine Soc Context: Normal glucose homeostasis is maintained despite reductions in insulin sensitivity by
increasing insulin secretion. This ability to compensate for reduced insulin sensitivity is highly
heritable, but the mechanisms for this compensation or its failure in type 2 diabetes ... Cited by 14 - Related articles - BL Direct - All 5 versions
PS Behn, J Wasson, S Chayen, I Smolovitch, … - DIABETES-NEW …, 1998 - Am Diabetes Assoc T ype 2 diabetes is a heterogeneous metabolic dis- order of largely unknown genetic
etiology. Matu- rity-onset diabetes of the young (MODY) is a vari- ant of this disorder that is distinguished
by a dom- inant Mendelian genetic transmission and an early age of onset. The first gene ... Cited by 16 - Related articles - BL Direct - All 5 versions
K Osei, DP Schuster - American journal of hypertension, 1996 - nature.com We sought to examine the association of insulin, insulin sensitivity, and blood pressure using
ambulatory blood pressure monitor in three ethnically distinct populations. The study population
comprised the following. Group 1 (n = 31): African-Americans; Group 2 (n = 27): recent ... Cited by 26 - Related articles - BL Direct - All 3 versions
