- ►diabetesjournals.org [PDF] M Stang, DK Wysowski, D Butler-Jones - Diabetes Care, 1999 - Am Diabetes Assoc The lactic acidosis rate in metform in users has been re po rted to be much
lower: 0–8.4 cases per 100,000 person-years (4–6). However, rates have been
based on passive re po rting of cases. The FDA identi- fied the need for a ... Cited by 114 - Related articles - BL Direct - All 6 versions
A Holstein, D Nahrwold, S Hinze, EH Egberts - Diabetic Medicine, 1999 - ingentaconnect.com Methods A cross-sectional analysis of 308 consecutive Type 2 diabetic patients
(mean age 66 T 11.3 years) previously treated with metformin on an outpatient
basis and admitted to a German general hospital during the period from 1 ... Cited by 57 - Related articles - BL Direct - All 5 versions
C Horlen, R Malone, B Bryant, B Dennis, T … - Jama, 2002 - Am Med Assoc To the Editor: Metformin is commonly used in the management of type 2 diabetes.
More than 25 million prescriptions for metformin were written in 2000, making it
the most commonly prescribed branded diabetes medication in the United ... Cited by 49 - Related articles - BL Direct - All 4 versions
RI Misbin, L Green, BV Stadel, JL Gueriguian … - The New England Journal of Medicine, 1998 - nejm.highwire.org On the basis of the reports received by the FDA, congestive heart failure has
recently been included as a contraindication to metformin therapy. The revised
label also states that metformin therapy should be withheld in patients ... Cited by 223 - Related articles - All 5 versions
JD Lalau, JM Race - Drug safety, 1999 - ingentaconnect.com Abstract Objective: The antidiabetic drug metformin has been associated in a
small num- ber of patients with lactic acidosis, a serious condition with a poor
prognosis. However, because of lack of data, the prognostic significance of ... Cited by 75 - Related articles - BL Direct - All 3 versions
TV Sulkin, D Bosman, AJ Krentz - Diabetes Care, 1997 - Am Diabetes Assoc OBJECTIVE: Treatment with metformin is occasionally associated with the
development of severe lactic acidosis. However, this is usually observed in
patients with major contraindications to the drug. In this study, we aimed ... Cited by 101 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org [PDF] JB Brown, K Pedula, J Barzilay, MK Herson, P … - Diabetes Care, 1998 - Am Diabetes Assoc Lactic acidosis is a life-threatening con- dition characterized by low arterial
pH ( 7.35) and elevated arterial lactate levels ( 5.0 mEq/l). It is the most
common metabolic acidosis in humans (1) and is usually a late-stage sequela ... Cited by 105 - Related articles - BL Direct - All 5 versions
- ►karolinskauniversitetssjukhuset.se [PDF] SR Salpeter, E Greyber, GA Pasternak, EE … - Archives of Internal Medicine, 2003 - archinte.highwire.org Methods A comprehensive search was performed to identify all comparative trials
or observational cohort studies published between January 1, 1959, and March 31,
2002, that evaluated metformin therapy, alone or in combination with other ... Cited by 320 - Related articles - BL Direct - All 16 versions
R Rachmani, I Slavachevski, Z Levi, BS Zadok … - European Journal of Internal Medicine, 2002 - Elsevier Background: The strict limiting criteria for the use of metformin in diabetes
mellitus stem largely from reports, in the 1970s, of mortality and lactic
acidosis associated with phenformin. Data about metformin are less clear ... Cited by 43 - Related articles - All 5 versions
AM Emslie-Smith, DIR Boyle, JMM Evans, F … - Diabet. Med, 2001 - interscience.wiley.com It is also possible that your web browser is not configured or not able to
display style sheets. In this case, although the visual presentation will be
degraded, the site should continue to be functional. We recommend using the ... Cited by 66 - Related articles - BL Direct - All 5 versions
