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Mealtime glucose regulation with nateglinide in healthy volunteers

- diabetesjournals.org
JB Kalbag, YH Walter, JR Nedelman, JF … - Diabetes Care, 2001 - Am Diabetes Assoc
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What's this? ... Diabetes Care 24:73-77, 2001 © 2001 by the American Diabetes
Association, Inc. ... From the Departments of Clinical Pharmacology (JBK, ...
Cited by 73 - Related articles - BL Direct - All 6 versions

Pancreatic beta-cell KATP channel activity and membrane-binding studies with nateglinide: …

- aspetjournals.org
S Hu, S Wang, B Fanelli, PA Bell, BE Dunning … - Journal of Pharmacology and Experimental …, 2000 - ASPET
Nateglinide (A-4166) is an amino acid derivative with insulinotrophic action in
clinical development for treatment of type 2 diabetes. The aim of this study was
to determine whether nateglinide's interaction at the K ATP ...
Cited by 115 - Related articles - BL Direct - All 3 versions

Nateglinide alone and in combination with metformin improves glycemic control by reducing …

- diabetesjournals.org [PDF] 
ES Horton, C Clinkingbeard, M Gatlin, J Foley … - Diabetes Care, 2000 - Am Diabetes Assoc
From the Joslin Diabetes Center (ESH), Boston, Massachusetts; the Idaho
Endocrine Specialists (CC), Boise, Idaho; the Cardiovascular, Metabolic and
Endocrine Department (MG, SM), Clinical Research Divi- sion; and the ...
Cited by 201 - Related articles - BL Direct - All 9 versions

[PDF] Rapid and short-acting mealtime insulin secretion with nateglinide controls both prandial …


M Hanefeld, KP Bouter, S Dickinson, C … - Diabetes Care, 2000 - Am Diabetes Assoc
F rom the Outpatient Department, Institute of Clinical Metabolic Research,
Medical Faculty, Technical Uni- versity of Dresden (MH), Dresden, Germany; Bosch
Medicentre (KPB), Den Bosch, the Netherlands; and N ova rtis Pharma AG (SD, ...
Cited by 147 - Related articles - BL Direct - All 7 versions

Importance of early insulin secretion


PA Hollander, SL Schwartz, MR Gatlin, SJ … - Diabetes Care, 2001 - Am Diabetes Assoc
RESULTS—During the liquid-meal challenge, nateglinide reduced the incremental
glucose area under the curve (AUC) more effectively than glyburide (Δ = −4.94
vs. −2.71 mmol · h/l, P < 0.05), whereas glyburide reduced fasting ...
Cited by 100 - Related articles - BL Direct - All 7 versions

[PDF] I mp roved Control of Mealtime Glucose Excursions With Coadministration of Nateglinide …


Y Hirschberg, AH Karara, AO Pietri, JF Mc … - Diabetes Care, 2000 - Am Diabetes Assoc
Subjects Ta rget enrollment comprised 12 male and female volunteers with type2
diabetes of at least 6 months' duration, between ages 30 and 70 years, within 10
to 60% of their normal weight range, with an HbA 1 c of 12.5%, and with ...
Cited by 60 - Related articles - BL Direct - All 4 versions

Long-term effects of glibenclamide and nateglinide upon pancreatic islet function in normal …


A Laghmich, L Ladriere, F Malaisse-Lagae, … - Pharmacological Research, 1999 - Elsevier
1. T Yada and S Fujitani, Action mechanisms of a novel hypoglycaemic agent
(A4166) in pancreatic B-cells analyzed by measuring cytosolic Ca concentration.
Diabetes (1992). ... 14. A Sener, F Malaisse-Lagae, SP Dufrane and WJ ...
Cited by 14 - Related articles - BL Direct - All 5 versions

Synergistic effects of nateglinide and meal administration on insulin secretion in patients …

- endojournals.org
L Keilson, S Mather, YH Walter, S … - Journal of Clinical Endocrinology & Metabolism, 2000 - Endocrine Soc
This study assessed the synergistic effects of nateglinide (a nonsulfonylurea
D-phenylalanine derivative) and meals on insulin secretion in 24 patients with
type 2 diabetes. Oral doses of 60 and 180 mg or 120 and 240 mg were ...
Cited by 90 - Related articles - BL Direct - All 5 versions

The effect of food on the oral bioavailability and the pharmacodynamic actions of the …


AH Karara, BE Dunning, JF McLeod - The Journal of Clinical Pharmacology, 1999 - jclinpharm.highwire.org
On behalf of: American College of Clinical Pharmacology ... KARARA ET AL THE IN
SULI NO TROPIC AGENT NATEGLINIDE PHAR MA COKI NET ICS AND PHAR MA CO DY NAM ICS
... The Ef fect of Food on the Oral Bioa vail abil ity
Cited by 56 - Related articles - BL Direct - All 6 versions

Mealtime glucose regulation by nateglinide in type-2 diabetes mellitus


YH Walter, DI Spratt, S Garreffa, JF McLeod - European journal of clinical pharmacology, 2000 - Springer
Abstract Objectives: Pharmacodynamic e ects of nate- glinide, a novel
antidiabetic agent, were investigated in patients with type-2 diabetes mellitus.
Methods: Ten patients participated in this single-center, double-blind, ...
Cited by 19 - Related articles - BL Direct - All 4 versions


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