- ►diabetesjournals.org SC Elbein, J Sun, E Scroggin, K Teng, SJ … - Diabetes Care, 2001 - Am Diabetes Assoc OBJECTIVE—We have demonstrated high heritability of insulin secretion measured
as acute insulin response to glucose times insulin sensitivity (disposition
index). Furthermore, we showed that obese normoglycemic family members of a ... Cited by 31 - Related articles - BL Direct - All 5 versions
LM 't Hart, JM Dekker, TW Van Haeften, JB … - Diabetologia, 2000 - Springer The sulphonylurea receptor (SUR) is a subunit of the ATP-sensitive potassium
channel (K ATP channel) in the pancreatic beta cell [1, 2]. The protein complex
is involved in regulation of insulin secretion from the beta cell in ... Cited by 30 - Related articles - BL Direct - All 3 versions
YO SHEVCHENKO, SJ Bale, JG Compton - BioTechniques, 2000 - cat.inist.fr The need continues to grow for mutation identification in genetic disease in
both research and clinical settings. We have developed a rapid nonradioactive
bidirectional dideoxy fingerprint mutation screening procedure that is ... Cited by 17 - Related articles - BL Direct - All 2 versions
AF Reis, G Velho - Diabetes & metabolism, 2002 - ncbi.nlm.nih.gov The pancreatic B-cell ATP-sensitive potassium channel (K(ATP)) is composed of
two distinct subunits, an inwardly rectifying ion channel forming the pore
(Kir6.2), and a regulatory subunit, namely the sulfonylurea receptor-1 ... Cited by 23 - Related articles - BL Direct
DL Goksel, K Fischbach, R Duggirala, BD … - Human genetics, 1998 - Springer Abstract The high-affinity sulfonylurea receptor (SUR1) gene regulates insulin
secretion and may play a role in type 2 diabetes. A silent variant in exon 31 of
SUR1 (AGG→AGA) was detected by single-strand conforma- tional ... Cited by 39 - Related articles - BL Direct - All 4 versions
SC Elbein, K Teng, K Eddings, D Hargrove, E … - Metabolism, 2000 - Elsevier Type 2 diabetes mellitus (T2DM) is strongly inherited, but the major genes for
this disease have been elusive. In contrast, early-onset, autosomal-dominant
diabetes results from at least 5 loci, of which hepatocyte nuclear factor ... Cited by 13 - Related articles - BL Direct - All 7 versions
MJ Zychma, J Gumprecht, K Strojek, W … - Medical science monitor: international medical journal …, 2002 - ncbi.nlm.nih.gov BACKGROUND: The presence of a complex phenotype of type 2 diabetes results from
impaired insulin secretion and action, whereas the mechanism of action of
sulfonylurea derivatives, most commonly used in the treatment of type 2 ... Cited by 14 - Related articles - All 2 versions
- ►endojournals.org SC Elbein, SJ Hasstedt, K Wegner, SE Kahn - Journal of Clinical Endocrinology & Metabolism, 1999 - Endocrine Soc Both defective insulin secretion and insulin resistance have been reported in
relatives of type 2 diabetic subjects. We tested 120 members of 26 families with
a type 2 diabetic sibling pair with a tolbutamide-modified, frequently ... Cited by 105 - Related articles - BL Direct - All 5 versions
L Ji, X Han, H Wang - Zhonghua yi xue za zhi, 1998 - ncbi.nlm.nih.gov OBJECTIVE: To test the role of Sulfonylurea receptor gene(SUR) in the
pathogenesis of NIDDM in Chinese population. METHODS: We studied the
polymorphisms of the SUR gene in intron 24 and exon 22 by polymerase chain ... Cited by 3 - Related articles - BL Direct
AF Reis, WZ Ye, D Dubois-Laforgue, C … - Human genetics, 2000 - Springer Abstract The sulfonylurea receptor (SUR1) of the pan- creatic beta-cell
ATP-sensitive potassium channel plays a key role in glucose-induced insulin
secretion. The A-al- lele of a single nucleotide polymorphism (SNP) in exon ... Cited by 42 - Related articles - BL Direct - All 4 versions
